Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization with the Ty21a Typhoid Vaccine in Humans
AuthorBooth, Jayaum S.
Patil, Seema A.
Barnes, Robin, DNP
Fraser, Claire M.
Greenwald, Bruce D.
Sztein, Marcelo B.
PublisherElsevier on behalf of the American Gastroenterological Association
MetadataShow full item record
AbstractThis study examines mucosal immune responses to administration of the oral Ty21a-typhoid vaccine in humans. Local antigen-specific CD8+-Tm responses were substantially different from those observed in human mucosal immune regulation and approaches to oral immunization.
CitationBooth, J.S., et al. (2017). Systemic and Terminal Ileum Mucosal Immunity Elicited by Oral Immunization with the Ty21a Typhoid Vaccine in Humans. Cellular and Molecular Gastroenterology and Hepatology, 4(3), 419-437.
SponsorsThis work was funded by National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS grants R01-AI036525, U19-AI082655 (Cooperative Center for Human Immunology), and U19-AI109776 (Center of Excellence for Translational Research). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health.
KeywordCD8+-T memory cells
lamina propria mononuclear cells
multifunctional T cells
Typhoid Fever--prevention & control
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/7409
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/