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dc.contributor.authorDowling, Thomas C.
dc.contributor.authorFrye, Reginald F.
dc.date.accessioned2012-01-11T16:34:49Z
dc.date.available2012-01-11T16:34:49Z
dc.date.issued1999
dc.identifier.citationDowling, T. C., & Frye, R. F. (1999). Determination of famotidine in human plasma and urine by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 732(1), 239-243, DOI: 10.1016/S0378-4347(99)00269-8en_US
dc.identifier.issn0378-4347
dc.identifier.urihttp://hdl.handle.net/10713/723
dc.description.abstractAn improved, rapid and specific high-performance liquid chromatographic assay was developed for the determination of famotidine in human plasma and urine. Plasma samples were alkalinized and the analyte and internal standard (cimetidine) extracted with water-saturated ethyl acetate. The extracts were reconstituted in mobile phase, and injected onto a C18 reversed-phase column; UV detection was set at 267 nm. Urine samples were diluted with nine volumes of a mobile phase-internal standard mixture prior to injection. The lower limits of quantification in plasma and urine were 75 ng/ml and 1.0 mg/ ml, respectively; intra- and inter-day coefficients of variation were #10.5%. This method is currently being used to support renal function studies assessing the use of intravenously administered famotidine to characterize cationic tubular secretion in man.en_US
dc.language.isoen_USen_US
dc.subjectFamotidineen_US
dc.titleDetermination of famotidine in human plasma and urine by high-performance liquid chromatographyen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0378-4347(99)00269-8
dc.identifier.ispublishedYesen_US
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