“Independent” reanalysis of landmark starch solutions trial was published by original authors
Description
Is a reanalysis of clinical trial data truly independent if 6 of the 8 authors are associated with the organization that administered the original study? Moreover, 3 of the 6 are among the authors of the initial article, one of whom was the principal investigator. Peter Doshi discusses the Crystalloid versus Hydroxyethyl Starch Trial (CHEST), lack of data transparency, and concerns over the validity of the reanalysisCitation
Doshi, P. (2017). "Independent" reanalysis of landmark starch solutions trial was published by original authors. BMJ, 358:j3552. DOI: 10.1136/bmj.j3552Keyword
data sharingCHEST
Crystalloid versus Hydroxyethyl Starch Trial
independent reanalysis
research transparency
Voluven
George Institute for Global Health
Duke Clinical Research Institute
Fresenius Kabi
Access to Information
Clinical Trials as Topic
Hydroxyethyl Starch Derivatives
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http://hdl.handle.net/10713/6914ae974a485f413a2113503eed53cd6c53
10.1136/bmj.j3552
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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/