Evaluation of a Novel Charcoal Cookie Formulation for Drug Adsorption
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AbstractStudy Objectives: To determine the relative effect of a new charcoal cookie formulation on the absorption of orally administered cimetidine compared to a standard aqueous charcoal product; to compare the relative palatability of the two products. Design: Prospective, open-label, three-way cross-over trial Setting: General Clinical Research Center at University of Maryland Medical Center Patients: 8 healthy volunteers (ages 18 to 35 years of age). Intervention: After an overnight fast, subjects ingested cimetidine 800 mg tablet. At 15 minutes after the cimetidine dose subjects ingested either water, 3 charcoal cookies (equivalent to 7.2 g charcoal) or 7.2 g of aqueous activated charcoal suspension. Measurements: Venous blood samples were obtained over an 8 hour period for noncompartmental pharmacokinetic analysis including AUC and Cmax. Subjects evaluated the palatability of each product using a visual analog scale (VAS). Main Results: Both charcoal products effectively adsorbed cimetidine resulting in decreased absorption of most of the cimetidine dose. There was no difference in median percent decrease in cimetidine AUC (mg*hr/L) for the charcoal suspension and charcoal cookie [91.8% vs 82.1%] (p=0.505]. Similarly, there was no difference in the median percent decrease in Cmax (mg/L) for the charcoal suspension and charcoal cookies [82.6% vs 64.0%] (p=0.574). The palatability taste scores on VAS were 2.32 ±0.83 for the charcoal cookie and 1.08 ± 0.70 for the charcoal suspension. There was a significant difference in the palatability scores (p=0.001). All products were well tolerated and there were no adverse events reported. Conclusions: A new charcoal cookie formulation is as effective as the aqueous charcoal suspension at reducing absorption of cimetidine. The charcoal cookie is more palatable than the aqueous charcoal suspension.
CitationKlein-Schwartz, W., Doyon, S., & Dowling, T. C. (2010). Drug adsorption efficacy and palatability of a novel charcoal cookie formulation. Pharmacotherapy, 30(9), 888-894, DOI:10.1592/phco.30.9.888.
SponsorsThe research was funded by an award from the Frontiers Fund Research Institute of the American College of Clinical Pharmacy. This work was supported by the University of Maryland General Clinical Research Center Grant M01 RR 16500, General Clinical Research Centers Program, National Center for Research Resources (NCRR), NIH.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/691
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