Tripartite treatment by radiation, hyperthermia and anti-OX40 immunotherapy potentiates tumor growth delay and tumor microenvironment immunomodulation in pancreatic cancer
dc.contributor.author | Alexander, Allen Abey | |
dc.date.accessioned | 2017-06-21T16:48:25Z | |
dc.date.available | 2018-01-10T19:37:37Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | http://hdl.handle.net/10713/6782 | |
dc.description | University of Maryland, Baltimore. Molecular Medicine. M.S. 2017 | en_US |
dc.description.abstract | Pancreatic cancer is the fourth most deadly cancer in the United States. Despite development in conventional treatment strategies the 5 year survival rate is only 7.7%. In this study we demonstrated that the tripartite treatment by combination of fractionated radiation therapy, hyperthermia and anti-OX40 immunotherapy (tripartite) led to significant impact on pancreatic cancer in mice. The treatment of mice with the tripartite treatment demonstrated significant tumor growth inhibition (p<0.0001) with no observable toxicity due to this treatment. Flow cytometric analysis of the tumor showed a shift in tumor microenvironment from immune suppressive to immune stimulatory with significantly higher CD4+ and CD8a+ (p<0.05) T lymphocytes. A significantly higher population of helper T cells and cytotoxic T cells was observed in the usually immune-deficient pancreatic cancer tumor microenvironment coupled with a decrease in the immunosuppressive microenvironment in the tumors of animals receiving the tripartite treatment is potentially the cause of the superior anti-tumor effect observed in animals receiving the tripartite treatment. | en_US |
dc.language.iso | en_US | en_US |
dc.subject | fractionated-radiation | en_US |
dc.subject | hyperthermia | en_US |
dc.subject | pancreatic cancer | en_US |
dc.subject | syngeneic mouse model | en_US |
dc.subject | tripartite | en_US |
dc.subject.lcsh | Pancreas--Cancer | en_US |
dc.subject.mesh | Fever | en_US |
dc.subject.mesh | Immunotherapy | en_US |
dc.title | Tripartite treatment by radiation, hyperthermia and anti-OX40 immunotherapy potentiates tumor growth delay and tumor microenvironment immunomodulation in pancreatic cancer | en_US |
dc.type | dissertation | en_US |
dc.contributor.advisor | Mahmood, Javed | |
dc.description.uriname | Full Text | en_US |
dc.contributor.orcid | 0000-0002-1825-1161 | |
refterms.dateFOA | 2019-02-19T18:18:18Z |