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dc.contributor.authorAlexander, Allen Abey*
dc.date.accessioned2017-06-21T16:48:25Z
dc.date.available2018-01-10T19:37:37Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/10713/6782
dc.descriptionUniversity of Maryland, Baltimore. Molecular Medicine. M.S. 2017en_US
dc.description.abstractPancreatic cancer is the fourth most deadly cancer in the United States. Despite development in conventional treatment strategies the 5 year survival rate is only 7.7%. In this study we demonstrated that the tripartite treatment by combination of fractionated radiation therapy, hyperthermia and anti-OX40 immunotherapy (tripartite) led to significant impact on pancreatic cancer in mice. The treatment of mice with the tripartite treatment demonstrated significant tumor growth inhibition (p<0.0001) with no observable toxicity due to this treatment. Flow cytometric analysis of the tumor showed a shift in tumor microenvironment from immune suppressive to immune stimulatory with significantly higher CD4+ and CD8a+ (p<0.05) T lymphocytes. A significantly higher population of helper T cells and cytotoxic T cells was observed in the usually immune-deficient pancreatic cancer tumor microenvironment coupled with a decrease in the immunosuppressive microenvironment in the tumors of animals receiving the tripartite treatment is potentially the cause of the superior anti-tumor effect observed in animals receiving the tripartite treatment.en_US
dc.language.isoen_USen_US
dc.subjectfractionated-radiationen_US
dc.subjecthyperthermiaen_US
dc.subjectpancreatic canceren_US
dc.subjectsyngeneic mouse modelen_US
dc.subjecttripartiteen_US
dc.subject.lcshPancreas--Canceren_US
dc.subject.meshFeveren_US
dc.subject.meshImmunotherapyen_US
dc.titleTripartite treatment by radiation, hyperthermia and anti-OX40 immunotherapy potentiates tumor growth delay and tumor microenvironment immunomodulation in pancreatic canceren_US
dc.typedissertationen_US
dc.contributor.advisorMahmood, Javed
dc.description.urinameFull Texten_US
dc.contributor.orcid0000-0002-1825-1161
refterms.dateFOA2019-02-19T18:18:18Z


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