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    C-Reactive Protein as a Biomarker of Oral Health and Risk of Cardiovascular Disease in Healthy and CV Disease Subjects

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    Author
    Alzalzalah, Ahmed
    Advisor
    Meiller, Timothy F.
    Date
    2017
    Type
    dissertation
    
    Metadata
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    Abstract
    Cardiovascular disease (CVD) is a leading global cause of death. Elevated CRP is considered a biomarker for the development of CVD. CRP is elevated in inflammatory periodontal diseases considered by a co-morbidity of CVD. This project contrasted CRP in young healthy, elderly healthy and elderly with CVD subjects relating these to gingival index (GI) and body-mass index (BMI) as parameters of inflammation. The data confirm a correlation between GI, BMI with CRP levels and in turn the risk of CVD. Selected young subjects had CRP levels similar to the elderly CVD subjects. This suggests that young healthy subjects with elevated GI, coupled with high BMI may be at a higher risk to develop CVD, as they age. Future studies should focus on these subjects longitudinally to assess the development of systemic disease, in particular CVD. Modalities to lower risk factors using CRP as a biomarker of efficacy may be developed.
    Description
    University of Maryland, Baltimore. Biomedical Sciences-Dental School. M.S. 2017
    Keyword
    BMI
    CRP
    CVD
    Age Factors
    Cardiovascular Diseases
    C-Reactive Protein
    Body Mass Index
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/6777
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    Theses and Dissertations School of Dentistry
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