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    Effect of drug-eluting nanoparticles (prednisolone) on injured pulp, in vivo

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    Author
    Choi, Seung Kee
    Advisor
    Masri, Radi, 1975-
    Date
    2017
    Type
    dissertation
    
    Metadata
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    Abstract
    Treatment of irreversible pulpitis is focused on removing the affected tooth structure including the pulp. Pharmacologic treatments may only help control symptoms of pulpitis. This study evaluated the effect of prednisolone-eluting nanoparticles on inflamed pulp in rat teeth. 48 adult rat molar teeth received cavity preparations. After 2 weeks of exposure, only one half of the group received prednisolone. Pulp tissues were harvested at 2, 4, and 24 weeks for PCR to obtain levels of TNF-α, IL-1β, PDGF-α, and TGF. The results were compared at the three time points with 2-way ANOVA and Tukey's HSD test. A p ≤ 0.05 was considered significant. Prednisolone-eluting nanoparticles significantly reduced the level of TGF (F = 4.435, p ≤ .041) but did not significantly affect the levels of TNF-α, IL-1β, and PDGF-α.
    Description
    University of Maryland, Baltimore. Biomedical Sciences-Dental School. M.S. 2017
    Keyword
    Nanoparticles--therapeutic use
    Pulpitis--therapy
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/6771
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    Theses and Dissertations School of Dentistry
    Theses and Dissertations All Schools

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