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    Cavernous nerve injury by radiotherapy potentiates erectile dysfunction in rats

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    Author
    Connors, Caroline
    Advisor
    Mahmood, Javed
    Date
    2017
    Type
    dissertation
    
    Metadata
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    Abstract
    Approximately 50% of prostate cancer patients receiving radiotherapy develop erectile dysfunction within 3-5 years. The precise role of radiation-induced neurogenic injury post-radiotherapy has not been fully established. The CNs are post-ganglionic parasympathetic nerves that assist in the penile erection, located beside the prostate. Male rats were exposed to RT, and erectile function, CN injury, and penile tissue damage were evaluated. Physiological, electrophysiological, and TEM analysis elucidated the extent of damage to CN. RT also significantly increased the mRNA and protein expression of neural damage markers in the MPG. A significant upregulation of both RhoA/ROCK1 mRNA and ROCK1 protein expression were observed in radiated MPG. This result will introduce a rationale for utilizing novel strategies to prevent CN damage post-RT, and the RhoA/ROCK signaling pathway could be a feasible future target pathway to mitigate RiED in prostate cancer patients.
    Description
    University of Maryland, Baltimore. Molecular Medicine. M.S. 2017
    Keyword
    cavernous nerve
    Prostate--Cancer
    Erectile Dysfunction
    Radiation
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/6769
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    Theses and Dissertations School of Medicine
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