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    Basolateral Amygdala Stimulation Evokes Feed-Forward Inhibition in the Medial Prefrontal Cortex

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    Author
    Dilgen, Jonathan E.
    Advisor
    O'Donnell, Patricio
    Date
    2011
    Type
    dissertation
    
    Metadata
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    Abstract
    The amygdala sends a strong projection to the prefrontal cortex (PFC) and both brain regions are critical for high order cognitive processes. This pathway may convey emotional and incentive-value related information to the PFC where it could be used to guide behaviors such as decision making and working memory. Behavioral studies have shown that both the amygdala and PFC are important for emotional processing and learning, but the underlying neural correlates remain unclear. Anatomy studies show that the basolateral amygdala (BLA) sends an excitatory projection to the medial PFC (mPFC). Paradoxically, electrophysiologic evidence indicates that most mPFC neurons are inhibited by BLA stimulation. This apparent incongruence could be explained if mPFC interneurons are considered mediators of BLA to mPFC neurotransmission. In this thesis, I tested the hypothesis that the BLA-mPFC projection includes a feed-forward inhibition mechanism with several experiments using electrophysiological approaches.
    Description
    University of Maryland in Baltimore. Neuroscience. Ph.D. 2011
    Keyword
    intracellular
    Amygdala
    Electrophysiology
    Prefrontal Cortex
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/609
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