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    Defective Natural Killer T cell development and function in BRCA1 mutant mice

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    Author
    Bates, Joshua Philip
    Advisor
    Webb, Tonya J.
    Date
    2016
    Type
    dissertation
    
    Metadata
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    Abstract
    NKT cells are significantly reduced in the blood of newly diagnosed breast cancer (BC) patients compared to healthy volunteers (HV). We hypothesize that one mechanism by which breast cancers escape immune detection is due to a loss in NKT cell number and function. Therefore, we used mice genetically predisposed to develop breast cancer (BRCA1-mut) to examine the phenotype and function of NKT cells throughout tumorigenesis. We found that BRCA1-mut mice have a 70-85% reduction of NKT cells in primary and secondary lymphoid organs, and that this reduction occurs in stage 3 of development. Moreover, the NKT cells of BRCA1-mut mice are functionally altered. Thus, our data suggest that NKT cells play a critical role in the development of breast tumorigenesis and further research is required to determine the mechanisms by which NKT cells are physically and functionally reduced in the absence of BRCA1.
    Description
    University of Maryland, Baltimore. Molecular Medicine. M.S. 2016
    Keyword
    BRCA1
    NKT
    Breast--Cancer
    Genes, BRCA1
    Immunotherapy
    Natural Killer T-Cells
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/5486
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    Theses and Dissertations School of Medicine
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