• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Mapping Brain Aldosterone and its Biosynthesis Using Mass Spectrometry

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Whitaker_umaryland_0373N_10727.pdf
    Size:
    1.359Mb
    Format:
    PDF
    Download
    Author
    Whitaker, Ian Griffith
    0000-0002-0009-0718
    Advisor
    Hamlyn, John M.
    Date
    2016
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Aldosterone is the primary mineralocorticoid steroid produced by the zona glomerulosa layer of the adrenal cortex. The primary actions of aldosterone on the kidney are well characterized while aldosterone has significant effects in other tissues. The presence of mineralocorticoid receptors in the brain, central infusion studies, and well documented behavioral and cognitive effects of hyperaldosteronism led to speculation that the brain is also a significant target site for aldosterone. However, circulating aldosterone is actively excluded by the blood brain barrier. To better understand the role of aldosterone in the brain, novel mass spectrometry approaches were used to determine the presence and amounts of the steroid within discrete brain regions. Aldosterone concentrations were found to be markedly elevated in discrete CNS areas (hotspots) but low in others. Tracer studies with 3H-DOC showed that aldosterone is locally synthesized within the CNS at sites that likely overlap with and contribute to hotspots in the brain. The biosynthesis and actions of local CNS aldosterone represent an independent control system of relevance to salt balance, blood pressure and cognition.
    Description
    University of Maryland, Baltimore. Molecular Medicine. M.S. 2016
    Keyword
    aldosterone biosynthesis
    Brain
    Central Nervous System
    Mass Spectrometry
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/5466
    Collections
    Theses and Dissertations School of Medicine
    Theses and Dissertations All Schools

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.