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    Assessment of the Functional Relevance of the Claustrum in Attention

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    Author
    Panicker, Matthew
    Advisor
    Mathur, Brian N. (Brian Neil)
    Date
    2016
    Type
    dissertation
    
    Metadata
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    Abstract
    The brain has a limited capacity to process the myriad sensory signals in the environment. To overcome this, the brain focuses to situationally relevant stimuli while filtering out irrelevant stimuli, a process known as attention. Volitional, or "top-down" attention (as opposed to reflexive or "bottom-up" attention) involves the coordination of frontal, more executive cortices with posterior, more primary cortices. Here, we hypothesize that the claustrum mediates top down signaling through its numerous cortical projections. Using optogenetic techniques in mice, projections between an executive region, anterior cingulate cortex (ACC), and the claustrum were manipulated in order to ascertain the role of the claustrum during performance on an attentional task. Silencing ACC afferents to claustrum or activating claustral afferents to ACC disrupted task performance. We conclude that the claustrum is involved with top-down preparatory attention and may also be involved in bottom-up attention.
    Description
    University of Maryland, Baltimore. Molecular Medicine. M.S. 2016
    Keyword
    claustrum
    Attention
    Basal Ganglia
    Behavior
    Optogenetics
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/5447
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    Theses and Dissertations School of Medicine
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