• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Lactobacillus Isolates That Stop the Growth of Shigella in Culture and Increase the Resistance of Cultured Epithelial Cells to Disruption by Shigella

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Thomas_umaryland_0373N_10640.pdf
    Size:
    879.2Kb
    Format:
    PDF
    Download
    Author
    Thomas, Carrie
    Advisor
    Stine, Oscar Colin
    Date
    2015
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Diarrheal disease is one of the leading causes of death among young children in low income regions of the world, and may be due to multiple factors, one such factor being microbial infection. Among the leading causes of microbial diarrhea is Shigella; at the moment there is no vaccine or probiotic treatment to counter the threat posed by Shigella. Our ultimate goal is to generate an effective and accessible probiotic treatment. Our group recently identified that the presence of certain Lactobacillus strains in the intestinal tract protect the human host from the effects of Shigella (p<0.02). Thus, we hypothesized that some strains of Lactobacillus from children with diarrhea in Kenya would either inhibit the growth of Shigella in culture, or increase the resistance of cultured intestinal epithelial cells to attack by Shigella. We collected six strains of Lactobacillus from children in Lwak, Kenya with diarrhea. Four produce soluble compounds that stopped the growth of Shigella in culture (p=10-136). One strain also produced a soluble compound(s) that increased the resistance of a cultured intestinal epithelial monolayer (T-84 cells) to disruption by Shigella (p=0.04). Once identified, these soluble compounds may be useful for treating or preventing Shigella infections and the Lactobacillus strains may be probiotic treatments for diarrhea caused by Shigella.
    Description
    University of Maryland, Baltimore. Epidemiology and Preventive Medicine. M.S. 2015
    Keyword
    optical density
    transepithelial electronic response
    Diarrhea
    Lactobacillus
    Probiotics
    Shigella
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/4621
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.