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dc.contributor.authorFaison, Shamia
dc.date.accessioned2015-06-29T20:37:07Z
dc.date.available2016-01-29T19:25:04Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10713/4614
dc.descriptionUniversity of Maryland, Baltimore. Pharmaceutical Sciences. Ph.D. 2015en_US
dc.description.abstractThe negative consequences of nicotine use are well known and documented, however, abstaining from nicotine use and achieving abstinence poses a major challenge for the majority of nicotine users trying to quit. l-Tetrahydropalmatine (l-THP), a compound extracted from the Chinese herb Corydalis, has been used clinically in China for over 40 years as a sedative and analgesic. l-THP has also displayed utility in the treatment of drug addiction, particularly cocaine and heroin addiction. The objective of this dissertation was to investigate if the utility of l-THP could be extended to include treatment of nicotine addiction. As such, the effect of l-THP treatment on abuse-related effects of nicotine was assessed in various behavioral models of nicotine addiction. Once the utility of l-THP was determined, the efficacy of l-THP was tested against varenicline and bupropion, FDA approved treatments for nicotine addiction. To better understand neurochemical changes that occur with l-THP administration, microdialysis experiments were performed where it was found that l-THP interacts with the mesolimbic dopamine system, a prominent pathway of drug addiction. The efficacy of l-THP in the treatment of various models of nicotine addiction and its interaction with the mesolimbic dopamine system make l-THP an attractive compound to study concerning nicotine addiction. Given the long standing safe use of l-THP in China and this new preclinical data, l-THP warrants further study and development for the treatment of nicotine addiction.en_US
dc.language.isoen_USen_US
dc.subjectaddictionen_US
dc.subjectlevo-tetrahydropalmatineen_US
dc.subject.lcshNicotine addiction--Treatmenten_US
dc.titleThe Development of levo-Tetrahydropalmatine as a Treatment for Nicotine Addictionen_US
dc.typedissertationen_US
dc.contributor.advisorWang, Jia Bei
dc.description.urinameFull Texten_US
dc.contributor.orcid0000-0002-4355-8624
refterms.dateFOA2019-02-21T03:22:48Z


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