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    Mapping of Cannabinoid Type 1 Receptor Inputs into Dopamine Neurons of the Ventral Tegmental Area

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    Author
    Kashtelyan, Vadim
    Advisor
    Cheer, Joseph F.
    Morales, Marisela
    Date
    2015
    Type
    dissertation
    
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    Abstract
    The mesolimbic dopamine (DA) pathway is critically involved in reward-seeking and appetitive behaviors. It originates in the ventral tegmental area (VTA) and provides DA innervation to terminal regions. Impaired DA transmission is a hallmark of schizophrenia, depression and drug abuse. The activity of DAergic cells is potently modulated by the endocannabinoid system (ECS). The ECS influences neuronal activity through presynaptic inhibition of neurotransmitter release. The cannabinoid type 1 receptor (CB1R) is the main receptor involved in this signaling pathway. Here, we identify inputs to VTA DA neurons that express CB1R mRNA. Using a series of viral vectors, we first identified monosynaptic inputs to DA neurons in the VTA. We then performed a combination of radioactive in situ hybridization and immunohistochemistry to label monosynaptic inputs expressing CB1R mRNA. Our results identify a population of VTA DA afferent neurons arising from the dorsal raphe nucleus that signal through the ECS.
    Description
    University of Maryland, Baltimore. Molecular Medicine. M.S. 2015
    Keyword
    cannabinoid type 1 receptor
    pseudo rabies virus
    Dopamine
    Ventral Tegmental Area
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/4590
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    Theses and Dissertations School of Medicine
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