• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Characterization of the Interaction between Candida albicans and Streptococcus mutans

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Mutawalli_umaryland_0373N_10514.pdf
    Size:
    28.47Mb
    Format:
    PDF
    Download
    Author
    Mutawalli, Khalid Hassan
    Advisor
    Jabra-Rizk, Mary Ann
    Date
    2014
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    The oral microbial communities are some of the most complex microbial floras in the human body. Occurrence of oral disease results from disturbance of the equilibrium of this ecosystem. Dental caries or tooth decay is the most common oral disease particularly in children characterized by irreversible destruction of the tooth mediated by demineralization of dental surfaces. These processes are the result of interactions between the various microbial species embedded in the biofilm formed on tooth surface known as dental plaque. These complex interactions between metabolically active microbial species cause fluctuations in pH ultimately resulting in dissolution of the dental hard tissues and formation of carious lesions. The bacterial species Streptococcus mutans has long been considered the etiologic agent of caries, however recent in vitro evidence seem to indicate a role for the fungal species Candida albicans in mediating cariogenic development via its physical and metabolic interactions with S. mutans. However, in depth investigations are required to determine mechanistically precise details of adhesion and signaling under conditions of co-existence. To that end, the goal of this proposal is to characterize the interaction between C. albicans and S. mutans using biologically relevant in vitro model systems. Specifically, we aim to demonstrate that the strong co-adherence of these diverse oral pathogens to each other and to oral surfaces results in the formation of mature biofilms, a pre-requisite for the development of dental caries. Importantly, as design of effective therapies to treat caries has been a challenge, this project also aimed to develop a novel antimicrobial bioadhesive hydrogel formulation for use as oral topical agent with targeted action geared towards blocking microbial adhesion to surfaces and in turn prevention and eradication of biofilms. The accomplishment of the work proposed in this project will provide crucial insights into the potential role of C albicans in the development of dental caries, an area of research that is yet to be explored. The ultimate goal is to contribute to our understanding of the various factors and conditions that play a role in microbial colonization and the progression of colonization to infection. Such crucial information will have important clinical implications as it aids in the identification and the design of novel therapeutic strategies aimed at the prevention and/or treatment of dental caries and oral infections in general. Significantly, the novel findings generated strongly indicate that the presence of C. albicans in the oral environment should be considered as an additional factor in evaluating risks of caries.
    Description
    University of Maryland, Baltimore. Biomedical Sciences-Dental School. M.S. 2014
    Keyword
    Candida albicans--pathogenicity
    Streptococcus mutans--pathogenicity
    Dental Caries--etiology
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/4071
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Dentistry

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.