Show simple item record

dc.contributor.authorSabti, Mohammad Y.
dc.date.accessioned2014-05-28T15:47:49Z
dc.date.available2014-05-28T15:47:49Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10713/4068
dc.descriptionUniversity of Maryland, Baltimore. Biomedical Sciences-Dental School. M.S. 2014en_US
dc.description.abstractProblem: Fear of a painful dental injection and subsequent avoidance behavior are significant barriers to regular visits to the dentist. An anesthetic procedure that would avoid the discomfort of a local anesthetic injection thus obviating fear and anxiety about receiving a "shot," would greatly benefit dental patients. Methods: The study employed a multi-center, randomized, double-blind, placebo-controlled, parallel-groups design to assess the safety and efficacy of Kovacaine Mist delivered intranasally for inducing pulpal anesthesia of maxillary teeth sufficient to allow completion of the Study Dental Procedure. A total of 36 subjects, randomized 2:1 (Kovacaine Mist: Placebo) were enrolled. Results: Kovacaine Mist was significantly superior to placebo (p<0.0001) with respect to the proportion of subjects who did not require rescue by injection of local anesthetic to complete the Study Dental Procedure. Conclusions: Based of the results of this clinical trial, a nasal anesthetic, such as kovacaine mist, could potentially be used as a safe and effective alternative to maxillary infiltration for anesthetizing maxillary premolars and anteriors to achieve pulpal anesthesia.en_US
dc.language.isoen_USen_US
dc.subjectefficacyen_US
dc.subjectintranasalen_US
dc.subject.meshAdministration, Intranasalen_US
dc.subject.meshAnesthesia, Dentalen_US
dc.subject.meshClinical Trialen_US
dc.subject.meshPainen_US
dc.subject.meshTetracaineen_US
dc.titleA Phase 3, Multi-Center, Randomized, Double-Blind, Parallel-Groups Clinical Trial Comparing the Efficacy and Safety of Intranasally Administered Kovacaine Mist to Placebo for Anesthetizing Maxillary Teeth in Adultsen_US
dc.typedissertationen_US
dc.contributor.advisorGordon, Sharon M.
refterms.dateFOA2019-02-19T17:43:38Z


Files in this item

Thumbnail
Name:
Sabti_umaryland_0373N_10495.pdf
Size:
1.004Mb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record