Browsing School of Dentistry by Subject "Bone Remodeling"
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Temporary anchorage devices for ridge preservation after extractionThe objective of this study is to investigate effects of transcortical mini-screws placed in the buccal plate of the extraction socket following tooth extraction in human subjects compared to untreated sockets. Patients planned for extraction of two maxillary premolars were recruited. One mini-screw was placed in the buccal plate of the extraction side on the experimental side. The contralateral extraction side was left untreated as the control side. Intraoral digital scans and clinical photographs were obtained at baseline, 4 months, and 8 months. CBCTs were exposed after the extraction and before mini-screw placement and at 8 months. A considerable decrease in ridge width was observed in all three subjects at experimental and control sides. However, the experimental sides exhibited less bone loss compared to the control sides in two subjects. Transcortical mini-screw placement in the buccal plate might reduce dimensional changes at the extraction side.
The Role of Nociceptors in Orthodontic Tooth Movement, Pain, and Alveolar Bone RemodelingObjective: To determine the effects of selectively ablating transient receptor potential vanilloid 1 (TRPV1)-expressing nociceptors on orthodontic tooth movement, pain, and alveolar bone remodeling. Methods: Resiniferatoxin (RTX) or vehicle was stereotaxically injected into left trigeminal ganglia in adult C57BL/6 mice. After 1 week, orthodontic spring was placed between left maxillary first molar and upper incisors. Pain level was evaluated by measuring mouse grimace scale (MGS) and bite force before and after 1, 3, and 7 days following the procedures. After 12 days, micro-CT was used to quantify tooth movement and analyzing alveolar bone changes. Results: Experimental tooth movement increased MGS scores and decreased bite force. RTX ablation of TRPV1+ nociceptors attenuated MGS scores and relieved the reduction in bite force. The extent of tooth movement was decreased in RTX-treated group, but interradicular alveolar bone volume was not affected. Conclusion: Selective ablation of TRPV1+ nociceptors significantly decreases tooth movement and pain.