• Improving rotavirus vaccine coverage: Can newer-generation and locally produced vaccines help?

      Deen, Jacqueline; Lopez, Anna Lena; Kanungo, Suman; Wang, Xuan-Yi; Anh, Dang Duc; Tapia, Milagritos D.; Grais, Rebecca F. (Taylor & Francis, 2017-12-21)
      There are two internationally available WHO-prequalified oral rotavirus vaccines (Rotarix and RotaTeq), two rotavirus vaccines licensed in India (Rotavac and Rotasiil), one in China (Lanzhou lamb rotavirus vaccine) and one in Vietnam (Rotavin-M1), and several candidates in development. Rotavirus vaccination has been rolled out in Latin American countries and is beginning to be deployed in sub-Saharan African countries but middle- and low-income Asian countries have lagged behind in rotavirus vaccine introduction. We provide a mini-review of the leading newer-generation rotavirus vaccines and compare then with Rotarix and Rotateq. We discuss how the development and future availability of newer-generation rotavirus vaccines that address the programmatic needs of poorer countries may help scale-up rotavirus vaccination where it is needed.