• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Occupational and Environmental Exposures, Genetic Polymorphisms and Bladder Cancer Risk among Male Farmers in Egypt

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Dawson_umaryland_0373D_10408.pdf
    Size:
    725.8Kb
    Format:
    PDF
    Download
    Author
    Dawson, Rebecca Smullin
    Advisor
    Amr, Sania
    Date
    2013
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    Objectives: To examine associations between bladder cancer risk and (1) farming as an occupation, (2) pesticide exposure, and (3) polymorphisms of the GSTM1, GSTT1, NQO1, and SOD2 genotypes among men farmers in Egypt, as well as (4) indirect exposure to farming among women living with a farmer. Methods: We used questionnaire and genotype data from a multicenter case-control study in Egypt. Cases confirmed to have either urothelial carcinoma (UC) or squamous cell carcinoma (SCC), and frequency-matched population controls were included. Unconditional logistic and polytomous (where appropriate) regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CIs). Results: Among the 1525 male cases confirmed as primary urinary bladder carcinomas and 2069 controls, we found that working as a farmer was significantly associated with increased bladder cancer risk for both smokers and non-smokers (AOR=1.72; 95% CI: 1.43-2.05, and AOR=3.46; 95% CI: 2.56-4.66, respectively) after adjustment for other known risk factors. To a lesser extent women living with farmers had increased odds of having bladder cancer (adjusted OR=1.33; 95% CI: 0.98-1.79). Among the men farmers (cases=885 and controls=840), pesticide exposure was associated with increased risk of UC type of cancer (OR=1.28; 95% CI: 1.01-1.61) and the odds of having UC increased as the duration and frequency of exposure to pesticides increased. Furthermore, the highest risk was found among exposed farmers with genes encoding for moderate to low activity of the enzymes NQO1 and SOD2. There were no associations between the GSTT1 and GSTM1 null genotypes and bladder cancer risks among Egyptian farmers. Conclusions: Our findings suggest that working as or living with a farmer is associated with increased bladder cancer risk in Egypt. Exposure to pesticides and polymorphisms of the NQO1 and SOD2 genotypes appear to be among the contributing risk factors.
    Description
    University of Maryland, Baltimore. Epidemiology and Public Health. Ph.D. 2013
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/2751
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.