• Login
    View Item 
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    •   UMB Digital Archive
    • School, Graduate
    • Theses and Dissertations All Schools
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    An integrated pharmacokinetic and pharmacodynamic study of acute marijuana use

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Find Full text
    Author
    Huestis, Marilyn
    Advisor
    Cone, Edward J.
    Date
    1992
    Type
    dissertation
    
    Metadata
    Show full item record
    Abstract
    An integrated pharmacokinetic and pharmacodynamic study of acute marijuana use in humans was designed to characterize the onset, peak, and duration of a broad range of marijuana's physiological and behavioral effects. The study design emphasized the critical smoking period, when {dollar}\Delta{dollar}9-tetrahydro-cannabinol (THC), the major active ingredient of marijuana, was absorbed and reached active sites. Six healthy males smoked a single marijuana cigarette (placebo, 1.75% or 3.55% THC) in a double-blind, randomized, Latin square study design. Advanced technologies were used which included a continuous withdrawal blood pump for rapid, integrated blood sampling; computerization of the paced smoking protocol and presentation and collection of behavioral measures; and THC and metabolite analysis by GC/MS. Previous studies have indicated a substantial time delay between peak plasma levels of THC and drug-induced effects. This study demonstrated that some behavioral and physiologic effects appear concurrently or shortly after the rapid appearance of THC in blood. The study design incorporated measurements of subjective effects after each marijuana inhalation to monitor the rapid onset of effects. Three of six subjects reported increases in drug "liking" and "feel drug" scores after the first puff. Maximum heart rates were recorded within 4 minutes of the last inhalation after the high dose cigarette. In addition, significant drug exposure was demonstrated after a single puff of marijuana smoke. Mean blood THC concentrations were 7.0 and 18.1 ng/mL following the first marijuana inhalation of a 1.75 or 3.55% THC cigarette, respectively. In addition, integrated blood sampling throughout the smoking process clearly demonstrated that peak THC levels occurred prior to the end of smoking. Blood cannabinoid data collected in this controlled clinical study were used for development of mathematical models for the prediction of elapsed time after marijuana use from the analysis of a single blood sample for cannabinoids. Corresponding confidence intervals were derived for future predictions at the 95% confidence level. The accuracy of model prediction was evaluated by comparison of the predicted time of prior drug use to the actual time of exposure and comparison of the actual time of use to the 95% confidence limits.
    Description
    University of Maryland, Baltimore. Toxicology. Ph.D. 1992
    Keyword
    Health Sciences, Toxicology
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/2506
    Collections
    Theses and Dissertations All Schools
    Theses and Dissertations School of Medicine

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.