A Pilot Study Assessing Retinal Blood Flow Dysregulation in Glaucoma Using Erythrocyte Mediated Velocimetry
AuthorChen, Victoria Y.
Le, Christopher T.
Magder, Laurence S.
Im, Lily T.
Saeedi, Osamah J.
JournalTranslational Vision Science & Technology
MetadataShow full item record
AbstractPurpose: The purpose of this study was to compare autoregulation of retinal arteriolar and venular blood flow in patients with glaucoma, glaucoma suspect participants, and control participants using erythrocyte mediated velocimetry. Methods: This prospective cohort pilot study included 7 eyes of 5 participants with glaucoma, 15 eyes of 8 glaucoma suspect participants, and 11 eyes of 6 control participants. Mean erythrocyte velocity in retinal arterioles and venules was measured using erythrocyte mediated velocimetry at room air and after oxygen supplementation. Change in erythrocyte velocity was compared among all groups using generalized estimating equations. Results: In total, 64 vessels (18 with glaucoma, 31 that were glaucoma suspect, and 15 controls) of 33 eyes of 19 participants were analyzed. There was no significant difference in baseline velocities in arterioles or venules among the three groups.With induction of hyperoxia, mean arterial erythrocyte velocity decreased in glaucoma (−7.2 ± 13.7%), which differed from controls and glaucoma suspectswhere erythrocyte velocity increased with hyperoxia by 4.6 ± 13.3% (P = 0.002) and 7.2 ± 21.7% (P = 0.03), respectively. A higher baseline arteriolar velocity (β =−3.9% per mm/s, P = 0.002), glaucoma diagnosis (β=−21.1%, P=0.03), andWhite race (β=−20.0%, P=0.01)were associated with decreased velocity in response to arterial hyperoxia. Conclusions:Hyperoxia increased erythrocyte velocity in control and glaucomasuspect participants, but decreased erythrocyte velocity in glaucoma participants, possibly due to impaired autoregulation. Baseline velocity, glaucoma diagnosis, andWhite race were associated with a decrease in velocity with induction of hyperoxia. Translational Relevance: Erythrocyte mediated angiography (EMA) permits precision measurements of blood flow which may aid in the development of biomarkers of glaucoma-related dysregulation of blood flow.
DescriptionThe article processing charges (APC) for this open access article were partially funded by the Health Sciences and Human Services Library's Open Access Publishing Fund for Early-Career Researchers
Rights/TermsAttribution-NonCommercial-NoDerivatives 4.0 International
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/20984
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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International