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Pancreatic cancer derived 3D organoids as a clinical tool to evaluate the treatment response

dc.contributor.authorShukla, Hem D.
dc.contributor.authorDukic, Tijana
dc.contributor.authorRoy, Sanjit
dc.contributor.authorBhandary, Binny
dc.contributor.authorGerry, Andrew
dc.contributor.authorPoirier, Yannick
dc.contributor.authorLamichhane, Narottam
dc.contributor.authorMolitoris, Jason
dc.contributor.authorCarrier, France
dc.contributor.authorBanerjee, Aditi
dc.contributor.authorRegine, William F.
dc.contributor.authorPolf, Jerimy C.
dc.date.accessioned2023-11-01T15:26:21Z
dc.date.available2023-11-01T15:26:21Z
dc.date.issued2023-01-12
dc.identifier.urihttp://hdl.handle.net/10713/20972
dc.descriptionThe article processing charges (APC) for this open access article were partially funded by the Health Sciences and Human Services Library's Open Access Publishing Fund for Early-Career Researchers.en_US
dc.description.abstractPancreatic cancer (PC) is the fourth leading cause of cancer death in both men and women. The standard of care for patients with locally advanced PC of chemotherapy, stereotactic radiotherapy (RT), or chemo-radiation-therapy has shown highly variable and limited success rates. However, three-dimensional (3D) Pancreatic tumor organoids (PTOs) have shown promise to study tumor response to drugs, and emerging treatments under in vitro conditions. We investigated the potential for using 3D organoids to evaluate the precise radiation and drug dose responses of in vivo PC tumors.en_US
dc.language.isoen_USen_US
dc.relation.ispartofFrontiers in Oncologyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectchemo-radiation therapyen_US
dc.subjecttreatment responseen_US
dc.subject.lcshPancreas--Canceren_US
dc.subject.lcshChemotherapyen_US
dc.subject.meshOrganoidsen_US
dc.subject.meshImaging, Three-Dimensionalen_US
dc.subject.meshDrug Therapyen_US
dc.subject.meshRadiotherapyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titlePancreatic cancer derived 3D organoids as a clinical tool to evaluate the treatment responseen_US
dc.typeArticleen_US
refterms.dateFOA2023-11-01T15:26:24Z


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International