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dc.contributor.authorDelaney, Megan
dc.contributor.authorHan, Zhe
dc.date.accessioned2023-03-02T18:39:02Z
dc.date.available2023-03-02T18:39:02Z
dc.date.issued2023-03-01
dc.identifier.urihttp://hdl.handle.net/10713/20396
dc.descriptionPoster presented at the 64th Annual Drosophila Research Conference, March 1, 2023.en_US
dc.description.abstractThe nephrocyte is the structural and functional equivalent of a human podocyte in Drosophila melanogaster, particularly the slit diaphragm. The nephrocyte was used to determine the relationship between nephrotic function, the actin and tubulin cytoskeletons, and their shared binding proteins. Of 18 shared binding proteins between the actin and tubulin cytoskeletons, the knockdown of Pigs results in the most dramatic phenotype. Immunofluorescent staining was used to see morphological differences in actin, tubulin, dual actin and tubulin binding protein, and insulin signaling genes. This information can be used to aid further research into causes and solutions to renal diseases such as Nephrotic Syndrome and Diabetic Nephropathyen_US
dc.language.isoen_USen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectnephrocyteen_US
dc.subject.meshDrosophilaen_US
dc.subject.meshCytoskeletonen_US
dc.subject.meshMicrotubulesen_US
dc.subject.meshChicagoen_US
dc.titleThe nephrocyte actin and tubulin cytoskeleton networks model slit diaphragm structural defects pertaining to podocyte pathogenesis (b)en_US
dc.typePoster/Presentationen_US
refterms.dateFOA2023-03-02T18:39:03Z


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International