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dc.contributor.authorGuo, Xiao
dc.contributor.authorSun, Yan
dc.contributor.authorWang, Zheng
dc.contributor.authorRen, Biao
dc.contributor.authorXu, Hockin H K
dc.contributor.authorPeng, Xian
dc.contributor.authorLi, Mingyun
dc.contributor.authorWang, Suping
dc.contributor.authorWang, Haohao
dc.contributor.authorWu, Yao
dc.contributor.authorWeir, Michael D
dc.contributor.authorZhou, Xuedong
dc.contributor.authorLan, Fang
dc.contributor.authorCheng, Lei
dc.date.accessioned2022-11-22T21:04:37Z
dc.date.available2022-11-22T21:04:37Z
dc.date.issued2022-10-28
dc.identifier.urihttp://hdl.handle.net/10713/20214
dc.description.abstractPersistent apical periodontitis is a critical challenge for endodontists. Developing root canal filling materials with continuous antibacterial effects and tightly sealed root canals are essential strategies to avoid the failure of root canal therapy and prevent persistent apical periodontitis. We modified the EndoREZ root canal sealer with the antibacterial material dimethylaminododecyl methacrylate (DMADDM) and magnetic nanoparticles (MNPs). The mechanical properties of the modified root canal sealer were tested. The biocompatibility of this sealer was verified in vitro and in vivo. Multispecies biofilms were constructed to assess the antibacterial effects of the modified root canal sealer. We applied magnetic fields and examined the extent of root canal sealer penetration in vitro and in vivo. The results showed that EndoREZ sealer containing 2.5% DMADDM and 1% MNP had biological safety and apical sealing ability. In addition, the modified sealer could increase the sealer penetration range and exert significant antibacterial effects on multispecies biofilms under an external magnetic field. According to the in vivo study, the apices of the root canals with the sealer containing 2.5% DMADDM and 1% MNP showed no significant resorption and exhibited only a slight increase in the periodontal ligament space, with a good inhibitory effect on persistent apical periodontitis.en_US
dc.description.urihttps://doi.org/10.3390/ijms232113137en_US
dc.language.isoenen_US
dc.relation.ispartof:International journal of molecular sciencesen_US
dc.subjectDMADDMen_US
dc.subjectbiofilmen_US
dc.subjectmagnetic nanoparticlesen_US
dc.subjectpersistent apical periodontitisen_US
dc.subjectroot canal sealeren_US
dc.titleThe Preventive Effect of A Magnetic Nanoparticle-Modified Root Canal Sealer on Persistent Apical Periodontitis.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms232113137
dc.identifier.pmid36361925
dc.source.journaltitleInternational journal of molecular sciences
dc.source.volume23
dc.source.issue21
dc.source.countrySwitzerland


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