One vaccine to counter many diseases? Modeling the economics of oral polio vaccine against child mortality and COVID-19.
AuthorChang, Angela Y
Avidan, Michael S
Benn, Christine S
Bertozzi, Stefano M
Khader, Shabaana A
Netea, Mihai G
Jamison, Dean T
JournalFrontiers in public health
MetadataShow full item record
AbstractIntroduction: Recent reviews summarize evidence that some vaccines have heterologous or non-specific effects (NSE), potentially offering protection against multiple pathogens. Numerous economic evaluations examine vaccines' pathogen-specific effects, but less than a handful focus on NSE. This paper addresses that gap by reporting economic evaluations of the NSE of oral polio vaccine (OPV) against under-five mortality and COVID-19. Materials and methods: We studied two settings: (1) reducing child mortality in a high-mortality setting (Guinea-Bissau) and (2) preventing COVID-19 in India. In the former, the intervention involves three annual campaigns in which children receive OPV incremental to routine immunization. In the latter, a susceptible-exposed-infectious-recovered model was developed to estimate the population benefits of two scenarios, in which OPV would be co-administered alongside COVID-19 vaccines. Incremental cost-effectiveness and benefit-cost ratios were modeled for ranges of intervention effectiveness estimates to supplement the headline numbers and account for heterogeneity and uncertainty. Results: For child mortality, headline cost-effectiveness was $650 per child death averted. For COVID-19, assuming OPV had 20% effectiveness, incremental cost per death averted was $23,000-65,000 if it were administered simultaneously with a COVID-19 vaccine <200 days into a wave of the epidemic. If the COVID-19 vaccine availability were delayed, the cost per averted death would decrease to $2600-6100. Estimated benefit-to-cost ratios vary but are consistently high. Discussion: Economic evaluation suggests the potential of OPV to efficiently reduce child mortality in high mortality environments. Likewise, within a broad range of assumed effect sizes, OPV (or another vaccine with NSE) could play an economically attractive role against COVID-19 in countries facing COVID-19 vaccine delays.
Rights/TermsCopyright © 2022 Chang, Aaby, Avidan, Benn, Bertozzi, Blatt, Chumakov, Khader, Kottilil, Nekkar, Netea, Sparrow and Jamison.
benefit-cost analyses (BCA)
heterologous (non-specific) effects of vaccines
oral polio vaccine (OPV)
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/20039
- Research protocol of two concurrent cluster-randomized trials: Real-life Effect of a CAMPaign with Measles Vaccination (RECAMP-MV) and Real-life Effect of a CAMPaign with Oral Polio Vaccination (RECAMP-OPV) on mortality and morbidity among children in rural Guinea-Bissau.
- Authors: Varma A, Jensen AKG, Thysen SM, Pedersen LM, Aaby P, Fisker AB
- Issue date: 2019 Nov 11
- Budget impact of polio immunization strategy for India: introduction of one dose of inactivated poliomyelitis vaccine and reductions in supplemental polio immunization.
- Authors: Khan MM, Sharma S, Tripathi B, Alvarez FP
- Issue date: 2017 Jan
- National Immunization Campaigns With Oral Polio Vaccine May Reduce All-cause Mortality: An Analysis of 13 Years of Demographic Surveillance Data From an Urban African Area.
- Authors: Andersen A, Fisker AB, Nielsen S, Rodrigues A, Benn CS, Aaby P
- Issue date: 2021 May 18
- The cost-effectiveness of alternative polio immunization policies in South Africa.
- Authors: Griffiths UK, Botham L, Schoub BD
- Issue date: 2006 Jul 17
- Childhood mortality after oral polio immunisation campaign in Guinea-Bissau.
- Authors: Aaby P, Hedegaard K, Sodemann M, Nhante E, Veirum JE, Jakobsen M, Lisse I, Jensen H, Sandström A
- Issue date: 2005 Feb 25
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