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dc.contributor.authorUysal, Ilkay Başak
dc.contributor.authorBoué, Vanina
dc.contributor.authorMurall, Carmen Lia
dc.contributor.authorGraf, Christelle
dc.contributor.authorSelinger, Christian
dc.contributor.authorHirtz, Christophe
dc.contributor.authorBernat, Claire
dc.contributor.authorRavel, Jacques
dc.contributor.authorReynes, Jacques
dc.contributor.authorBonneau, Marine
dc.contributor.authorRahmoun, Massilva
dc.contributor.authorSegondy, Michel
dc.contributor.authorBoulle, Nathalie
dc.contributor.authorGrasset, Sophie
dc.contributor.authorGroc, Soraya
dc.contributor.authorWaterboer, Tim
dc.contributor.authorTribout, Vincent
dc.contributor.authorBravo, Ignacio G
dc.contributor.authorBurrel, Sonia
dc.contributor.authorFoulongne, Vincent
dc.contributor.authorAlizon, Samuel
dc.contributor.authorTessandier, Nicolas
dc.date.accessioned2022-09-21T16:28:08Z
dc.date.available2022-09-21T16:28:08Z
dc.date.issued2022-08-19
dc.identifier.urihttp://hdl.handle.net/10713/19827
dc.description.abstractHuman papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of the latter in cervical cancer is controversial but its long-term infections might modulate the mucosal microenvironment in a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, and studying the immunological and microbiological dynamics in the early stages of these infections may help identify or rule out potential interactions. We report two cases of concomitant productive, although asymptomatic, HSV-2 and HPV infections in young women (aged 20 and 25). The women were followed up for approximately a year, with clinical visits every two months and weekly self-samples. We performed quantitative analyses of their HSV-2 and HPV viral loads, immunological responses (IgG and IgM antibodies and local cytokines expression profiles), vaginal microbiota composition, as well as demographic and behavior data. We detect interactions between virus loads, immune response, and the vaginal microbiota, which improve our understanding of HSV-2 and HPVs' coinfections and calls for further investigation with larger cohorts.en_US
dc.description.urihttps://doi:10.1016/j.idcr.2022.e01604en_US
dc.language.isoenen_US
dc.relation.ispartofIDCasesen_US
dc.rights© 2022 Published by Elsevier Ltd.en_US
dc.subjectCST, Community State Typeen_US
dc.subjectCo-infectionen_US
dc.subjectHPV, Human papillomavirusen_US
dc.subjectHSV-2, Herpes Simplex Virus-2en_US
dc.subjectHerpes Simplex Virus-2en_US
dc.subjectHuman papillomavirusen_US
dc.subjectInteractionen_US
dc.subjectSTI, Sexually Transmitted Infectionen_US
dc.subjectVaginal microbiotaen_US
dc.subjectqPCRen_US
dc.subjectqPCR, quantitative PCRsen_US
dc.titleConcomitant and productive genital infections by HSV-2 and HPV in two young women: A case report.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.idcr.2022.e01604
dc.source.journaltitleIDCases
dc.source.volume30
dc.source.beginpagee01604
dc.source.endpage
dc.source.countryNetherlands


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