Concomitant and productive genital infections by HSV-2 and HPV in two young women: A case report.
AuthorUysal, Ilkay Başak
Murall, Carmen Lia
Bravo, Ignacio G
MetadataShow full item record
AbstractHuman papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of the latter in cervical cancer is controversial but its long-term infections might modulate the mucosal microenvironment in a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, and studying the immunological and microbiological dynamics in the early stages of these infections may help identify or rule out potential interactions. We report two cases of concomitant productive, although asymptomatic, HSV-2 and HPV infections in young women (aged 20 and 25). The women were followed up for approximately a year, with clinical visits every two months and weekly self-samples. We performed quantitative analyses of their HSV-2 and HPV viral loads, immunological responses (IgG and IgM antibodies and local cytokines expression profiles), vaginal microbiota composition, as well as demographic and behavior data. We detect interactions between virus loads, immune response, and the vaginal microbiota, which improve our understanding of HSV-2 and HPVs' coinfections and calls for further investigation with larger cohorts.
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KeywordCST, Community State Type
HPV, Human papillomavirus
HSV-2, Herpes Simplex Virus-2
Herpes Simplex Virus-2
STI, Sexually Transmitted Infection
qPCR, quantitative PCRs
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/19827