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dc.contributor.authorKodama, Joe
dc.contributor.authorWilkinson, Kevin J.
dc.contributor.authorIwamoto, Masahiro
dc.contributor.authorOtsuru, Satoru
dc.contributor.authorEnomoto-Iwamoto, Motomi
dc.date.accessioned2022-09-16T13:59:25Z
dc.date.available2022-09-16T13:59:25Z
dc.date.issued2022-12-01
dc.identifier.urihttp://hdl.handle.net/10713/19805
dc.description.abstractEndochondral bone formation is an important pathway in fracture healing, involving the formation of a cartilaginous soft callus and the process of cartilage-to-bone transition. Failure or delay in the cartilage-to-bone transition causes an impaired bony union such as nonunion or delayed union. During the healing process, multiple types of cells including chondrocytes, osteoprogenitors, osteoblasts, and endothelial cells coexist in the callus, and inevitably crosstalk with each other. Hypertrophic chondrocytes located between soft cartilaginous callus and bony hard callus mediate the crosstalk regulating cell-matrix degradation, vascularization, osteoclast recruitment, and osteoblast differentiation in autocrine and paracrine manners. Furthermore, hypertrophic chondrocytes can become osteoprogenitors and osteoblasts, and directly contribute to woven bone formation. In this review, we focus on the roles of hypertrophic chondrocytes in fracture healing and dissect the intermingled crosstalk in fracture callus during the cartilage-to-bone transition.en_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.description.urihttps://doi.org/10.1016/j.bonr.2022.101616en_US
dc.language.isoen_USen_US
dc.relation.ispartofBone Reportsen_US
dc.subjectCallusen_US
dc.subjectEndochondral bone formationen_US
dc.subjectFractureen_US
dc.subjectHypertrophic chondrocyteen_US
dc.subjectVascularizationen_US
dc.titleThe role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healingen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bonr.2022.101616
dc.source.journaltitleBone Reports
dc.source.volume17


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