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    The role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healing

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    Author
    Kodama, Joe
    Wilkinson, Kevin J.
    Iwamoto, Masahiro
    Otsuru, Satoru
    Enomoto-Iwamoto, Motomi
    Date
    2022-12-01
    Journal
    Bone Reports
    Type
    Article
    
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    Show full item record
    See at
    https://doi.org/10.1016/j.bonr.2022.101616
    Abstract
    Endochondral bone formation is an important pathway in fracture healing, involving the formation of a cartilaginous soft callus and the process of cartilage-to-bone transition. Failure or delay in the cartilage-to-bone transition causes an impaired bony union such as nonunion or delayed union. During the healing process, multiple types of cells including chondrocytes, osteoprogenitors, osteoblasts, and endothelial cells coexist in the callus, and inevitably crosstalk with each other. Hypertrophic chondrocytes located between soft cartilaginous callus and bony hard callus mediate the crosstalk regulating cell-matrix degradation, vascularization, osteoclast recruitment, and osteoblast differentiation in autocrine and paracrine manners. Furthermore, hypertrophic chondrocytes can become osteoprogenitors and osteoblasts, and directly contribute to woven bone formation. In this review, we focus on the roles of hypertrophic chondrocytes in fracture healing and dissect the intermingled crosstalk in fracture callus during the cartilage-to-bone transition.
    Sponsors
    National Institutes of Health
    Keyword
    Callus
    Endochondral bone formation
    Fracture
    Hypertrophic chondrocyte
    Vascularization
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19805
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.bonr.2022.101616
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