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dc.contributor.authorTarasiewicz, Agnieszka
dc.date.accessioned2022-09-14T13:49:43Z
dc.date.available2022-09-14T13:49:43Z
dc.date.issued2022
dc.identifier.urihttp://hdl.handle.net/10713/19797
dc.descriptionUniversity of Maryland, Baltimore. Cellular & Molecular Biomedical Sciences. M.S. 2022en_US
dc.description.abstractHypothyroidism prevalence among pregnant women is between 0.5 to 4% (Carney et al., 2014). Most studies look at the prolonged or severe reduction in thyroid hormone (TH) levels. We looked at how the reduced levels of TH during the third trimester of human gestation and the first weeks after birth in rodents impact the visual system. Additionally, we try to answer whether PTU treatment would affect neuronal plasticity in the visual cortex. We used the Visual Evoked Potential recordings to assess contrast sensitivity, spatial frequency acuity, and ocular dominance plasticity. In addition, we look into the expression of the photoreceptors in the retina. PTU exposure impacts the contrast sensitivity but not the spatial frequency acuity or ocular dominance plasticity. The expression level of the photoreceptor Opsin-M was also impacted. The reduced levels of the thyroid hormones during this crucial time have long-lasting consequences for the proper visual system processing.en_US
dc.language.isoen_USen_US
dc.subjectphotoreceptorsen_US
dc.subject.lcshHypothyroidismen_US
dc.subject.lcshDominance, Ocularen_US
dc.subject.lcshVisual Cortexen_US
dc.subject.lcshPregnancyen_US
dc.titleVisual Deficits in a Model of Gestational Hypothyroidismen_US
dc.typedissertationen_US
dc.date.updated2022-09-06T19:12:53Z
dc.language.rfc3066en
dc.contributor.advisorMedina, Alexandre E.
refterms.dateFOA2022-09-14T13:49:44Z


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