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    Treatment Patterns and Standardized Outcome Assessments Among Patients With Inflammatory Conditions of the Pouch in a Prospective Multicenter Registry.

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    Author
    Barnes, Edward L
    Deepak, Parakkal
    Beniwal-Patel, Poonam
    Raffals, Laura
    Kayal, Maia
    Dubinsky, Marla
    Chang, Shannon
    Higgins, Peter D R
    Barr, Jennifer I
    Galanko, Joseph
    Jiang, Yue
    Cross, Raymond K
    Long, Millie D
    Herfarth, Hans H
    Show allShow less

    Date
    2022-08-02
    Journal
    Crohn's & Colitis 360
    Publisher
    Crohn’s & Colitis Foundation
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/crocol/otac030
    Abstract
    Background. Much of our understanding about the natural history of pouch-related disorders has been generated from selected populations. We designed a geographically diverse, prospective registry to study the disease course among patients with 1 of 4 inflammatory conditions of the pouch. The primary objectives in this study were to demonstrate the feasibility of a prospective pouch registry and to evaluate the predominant treatment patterns for pouch-related disorders. Methods. We used standardized diagnostic criteria to prospectively enroll patients with acute pouchitis, chronic antibiotic-dependent pouchitis (CADP), chronic antibiotic refractory pouchitis (CARP), or Crohn’s disease (CD) of the pouch. We obtained detailed clinical and demographic data at the time of enrollment, along with patient-reported outcome (PRO) measures. Results. We enrolled 318 patients (10% acute pouchitis, 27% CADP, 12% CARP, and 51% CD of the pouch). Among all patients, 55% were on a biologic or small molecule therapy. Patients with CD of the pouch were more likely to use several classes of therapy (P < .001). Among patients with active disease at the time of enrollment, 23% with CARP and 40% with CD of the pouch were in clinical remission at 6 months after enrollment. Conclusions. In a population where most patients had refractory inflammatory conditions of the pouch, we established a framework to evaluate PROs and clinical effectiveness. This infrastructure will be valuable for long-term studies of real-world effectiveness for pouch-related disorders.
    Rights/Terms
    © The Author(s) 2022. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.
    Keyword
    Crohn’s disease of the pouch
    ileal pouch-anal anastomosis
    pouchitis
    real-world effectiveness
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19722
    ae974a485f413a2113503eed53cd6c53
    10.1093/crocol/otac030
    Scopus Count
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