Tibiofemoral knee osteoarthritis progresses symmetrically by knee compartment in the GOGO cohort.
AuthorAlexander, Louie C
Huebner, Janet L
Jordan, Joanne M
Renner, Jordan B
Wilson, Anthony G
Hochberg, Marc C
Kraus, Virginia Byers
JournalOsteoarthritis and cartilage open
MetadataShow full item record
AbstractObjective. To evaluate the degree of symmetry of knee osteoarthritis (OA) structural severity and progression of participants with a mean follow-up time of 3.8 years. Design. Participants from the Genetics of Generalized Osteoarthritis (GOGO) study (n = 705) were selected on the basis of radiographic evidence of OA in at least 1 knee, availability of radiographs at baseline and follow-up, and no history of prior knee injury or surgery. Incidence and progression of osteoarthritis were determined by radiographic Kellgren-Lawrence (KL) grade; compartmental OA progression was determined by change in joint space width of lateral and medial tibiofemoral compartments. Total OA progression was the sum of change in KL grade of both knees. Results. Compared with left knees, right knees had more severe KL grades at baseline (p = 0.0002) and follow-up (p = 0.0004), McNemar's χ2 = 34.16 and 26.08, respectively; however, both knees progressed similarly (p = 0.121, McNemar's χ2 = 10.09). Compartmental changes were symmetric across knees: medial r = 0.287, p = 0.0002; lateral r = 0.593, p = 0.0002. Change in joint space width in the medial compartment was negatively correlated with change in the lateral compartment of the same knee (left knees: r = −0.293, p = 0.021; right knees: r = −0.195, p = 0.0002). Conclusions. Although right knees tended to have more severe OA at both baseline and follow-up, radiographic progression did not differ by knee and compartmental progression correlated across knees. Given this trend in generalized OA, the risk of progression for both knees should be considered, even if only one knee has radiographic OA at baseline.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/19721
- Medial compartment defects progress at a more rapid rate than lateral cartilage defects in older adults with minimal to moderate knee osteoarthritis (OA): data from the OA initiative.
- Authors: Everhart JS, Abouljoud MM, Poland SG, Flanigan DC
- Issue date: 2019 Aug
- Baseline trabecular bone and its relation to incident radiographic knee osteoarthritis and increase in joint space narrowing score: directional fractal signature analysis in the MOST study.
- Authors: Podsiadlo P, Nevitt MC, Wolski M, Stachowiak GW, Lynch JA, Tolstykh I, Felson DT, Segal NA, Lewis CE, Englund M
- Issue date: 2016 Oct
- A new approach yields high rates of radiographic progression in knee osteoarthritis.
- Authors: Felson DT, Nevitt MC, Yang M, Clancy M, Niu J, Torner JC, Lewis CE, Aliabadi P, Sack B, McCulloch C, Zhang Y
- Issue date: 2008 Oct
- Serum hyaluronic acid concentration predicts the progression of joint space narrowing in normal knees and established knee osteoarthritis - a five-year prospective cohort study.
- Authors: Sasaki E, Tsuda E, Yamamoto Y, Maeda S, Inoue R, Chiba D, Fujita H, Takahashi I, Umeda T, Nakaji S, Ishibashi Y
- Issue date: 2015 Oct 10
- Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis.
- Authors: Sharma L, Hurwitz DE, Thonar EJ, Sum JA, Lenz ME, Dunlop DD, Schnitzer TJ, Kirwan-Mellis G, Andriacchi TP
- Issue date: 1998 Jul