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dc.contributor.authorCanakis, Andrew
dc.contributor.authorDeliwala, Smit S
dc.contributor.authorKadiyala, Jagannath
dc.contributor.authorBomman, Shivanand
dc.contributor.authorCanakis, Justin
dc.contributor.authorBilal, Mohammad
dc.date.accessioned2022-09-07T13:27:03Z
dc.date.available2022-09-07T13:27:03Z
dc.date.issued2022-07-30
dc.identifier.urihttp://hdl.handle.net/10713/19679
dc.description.abstractBackground: Gastric cancer (GC) represents a significant global health burden with high morbidity and mortality, especially when diagnosed at advanced stages. Therefore, early detection of GC is critical. Probe-based confocal laser endomicroscopy (pCLE) is a new evolving technology that uses real-time, high-resolution imaging to inspect the mucosa at the cellular and microvascular level, using a confocal probe. Widespread studies using pCLE are limited at the current time. We aimed to investigate the diagnostic efficacy of this modality for the detection of GC. Methods: Multiple databases were searched from inception until November 2021. The diagnostic performance of pCLE was assessed by calculating its sensitivity, specificity and accuracy for the detection of GC, using pooled proportions and 95% confidence intervals (CI) with a random-effects model. Heterogeneity was assessed using I2. Results: Seven studies were included, with a total of 567 patients (mean age 61.7 years, 364 males). Pooled performance metrics of pCLE included a sensitivity of 87.9% (95%CI 81.4-92.4; P<0.001; I2=0%), specificity 96.5% (95%CI 91.5-98.6; P<0.001; I2=51.84%), and an accuracy of 94.7% (95%CI 89.5-97.4; P<0.001; I2=65.44%). Conclusions: pCLE is a highly effective diagnostic modality for detecting GC. Larger, randomized controlled studies are needed to determine its role in daily practice compared to conventional endoscopic practices.en_US
dc.description.urihttps://doi.org/10.20524/aog.2022.0741en_US
dc.language.isoenen_US
dc.publisherHellenic Society of Gastroenterologyen_US
dc.relation.ispartofAnnals of gastroenterologyen_US
dc.rightsCopyright: © Hellenic Society of Gastroenterology.en_US
dc.subjectProbe-based confocal laser endomicroscopyen_US
dc.subjectgastric adenocarcinomaen_US
dc.subjectgastric canceren_US
dc.subjectscreeningen_US
dc.titleThe diagnostic performance of probe-based confocal laser endomicroscopy in the detection of gastric cancer: a systematic review and meta-analysis.en_US
dc.typeArticleen_US
dc.identifier.doi10.20524/aog.2022.0741
dc.identifier.pmid36061161
dc.source.journaltitleAnnals of gastroenterology
dc.source.volume35
dc.source.issue5
dc.source.beginpage496
dc.source.endpage502
dc.source.countryGreece


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