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    The diagnostic performance of probe-based confocal laser endomicroscopy in the detection of gastric cancer: a systematic review and meta-analysis.

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    Author
    Canakis, Andrew
    Deliwala, Smit S
    Kadiyala, Jagannath
    Bomman, Shivanand
    Canakis, Justin
    Bilal, Mohammad
    Date
    2022-07-30
    Journal
    Annals of gastroenterology
    Publisher
    Hellenic Society of Gastroenterology
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.20524/aog.2022.0741
    Abstract
    Background: Gastric cancer (GC) represents a significant global health burden with high morbidity and mortality, especially when diagnosed at advanced stages. Therefore, early detection of GC is critical. Probe-based confocal laser endomicroscopy (pCLE) is a new evolving technology that uses real-time, high-resolution imaging to inspect the mucosa at the cellular and microvascular level, using a confocal probe. Widespread studies using pCLE are limited at the current time. We aimed to investigate the diagnostic efficacy of this modality for the detection of GC. Methods: Multiple databases were searched from inception until November 2021. The diagnostic performance of pCLE was assessed by calculating its sensitivity, specificity and accuracy for the detection of GC, using pooled proportions and 95% confidence intervals (CI) with a random-effects model. Heterogeneity was assessed using I2. Results: Seven studies were included, with a total of 567 patients (mean age 61.7 years, 364 males). Pooled performance metrics of pCLE included a sensitivity of 87.9% (95%CI 81.4-92.4; P<0.001; I2=0%), specificity 96.5% (95%CI 91.5-98.6; P<0.001; I2=51.84%), and an accuracy of 94.7% (95%CI 89.5-97.4; P<0.001; I2=65.44%). Conclusions: pCLE is a highly effective diagnostic modality for detecting GC. Larger, randomized controlled studies are needed to determine its role in daily practice compared to conventional endoscopic practices.
    Rights/Terms
    Copyright: © Hellenic Society of Gastroenterology.
    Keyword
    Probe-based confocal laser endomicroscopy
    gastric adenocarcinoma
    gastric cancer
    screening
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19679
    ae974a485f413a2113503eed53cd6c53
    10.20524/aog.2022.0741
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