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dc.contributor.authorYi, ByongYong
dc.contributor.authorMossahebi, Sina
dc.contributor.authorModiri, Arezoo
dc.contributor.authorNichols, Elizabeth M
dc.contributor.authorGuerrero, Mariana
dc.contributor.authorLamichhane, Narottam
dc.contributor.authorMohindra, Pranshu
dc.date.accessioned2022-09-07T13:24:22Z
dc.date.available2022-09-07T13:24:22Z
dc.date.issued2022-06-28
dc.identifier.urihttp://hdl.handle.net/10713/19678
dc.description.abstractPurpose: To investigate whether volumetric-modulated proton arc therapy (VPAT) plans generate comparable doses to organs at risk (OARs) compared with interstitial high-dose-rate (iHDR) brachytherapy for patients with gynecologic cancer with disease extension to parametrial/pelvic side wall, who are not eligible for the aggressive procedure. Materials and methods: VPAT delivers proton arc beams by modulated energies at the beam nozzle while maintaining the same incident energy to the gantry during the arc rotation. Plans of 10 patients previously treated with iHDR brachytherapy for high-risk clinical treatment volumes (HRCTV; 31.8-110.6 cm3; lateral dimensions, 4.2-5.6 cm) were selected and compared with VPAT plans. VPAT plans for each patient were designed using a 152- to 245-MeV range of energy-modulated proton beams. Results: HRCTV coverage of the VPAT plans was comparable to that of the iHDR plans, with V150% showing no statistical differences. On average, the V100% and V90% of VPAT plans were higher than those of the iHDR plans, 95.0% vs 91.9% (P = .02) and 98.6% vs 97.5% (P = .02), respectively. D100 was also 17% higher for the VPAT plans (P = .03). On average, the D2cm3 of bladder, rectum, and small bowels in the VPAT plans were considerably lower than those in iHDR plans (by 17.4%, 35.2%, and 65.6%, respectively; P < .05 for all OARs). Conclusion: VPAT-generated plans were dosimetrically superior to those with HDR brachytherapy with interstitial needles for locally advanced gynecologic cancer with parametrial/pelvic side wall disease extension. Dosimetrically, VPAT provides a noninvasive alternative to iHDR brachytherapy with a superior dosimetric profile.en_US
dc.description.urihttps://doi.org/10.14338/IJPT-22-00013.1en_US
dc.language.isoenen_US
dc.publisherAllen Pressen_US
dc.relation.ispartofInternational journal of particle therapyen_US
dc.rights©Copyright 2022 The Author(s).en_US
dc.subjectinterstitial brachytherapyen_US
dc.subjectlocally advanced gynecologic canceren_US
dc.subjectproton arc therapyen_US
dc.titleProton Arc Therapy vs Interstitial HDR Brachytherapy in Gynecologic Cancer with Parametrial/pelvic Side Wall Extension.en_US
dc.typeArticleen_US
dc.identifier.doi10.14338/IJPT-22-00013.1
dc.identifier.pmid36060416
dc.source.journaltitleInternational journal of particle therapy
dc.source.volume9
dc.source.issue2
dc.source.beginpage31
dc.source.endpage39
dc.source.countryUnited States


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