Show simple item record

dc.contributor.authorLiu, Yongzhen
dc.contributor.authorPark, Debby
dc.contributor.authorCafiero, Thomas R
dc.contributor.authorBram, Yaron
dc.contributor.authorChandar, Vasuretha
dc.contributor.authorTseng, Anna
dc.contributor.authorGertje, Hans P
dc.contributor.authorCrossland, Nicholas A
dc.contributor.authorSu, Lishan
dc.contributor.authorSchwartz, Robert E
dc.contributor.authorPloss, Alexander
dc.date.accessioned2022-08-31T17:38:31Z
dc.date.available2022-08-31T17:38:31Z
dc.date.issued2022-07-09
dc.identifier.urihttp://hdl.handle.net/10713/19649
dc.description.abstractPatient-derived HBV infectious clones replicated robustly both in vitro and in vivo. GTs A and D induce more pronounced intrahepatic and proinflammatory cytokine responses which correlated with faster viral clearance. Notably, all 5 HBV clones robustly produced viral particles following transfection into HepG2 cells, and these particles were infectious in HepG2-NTCP cells, primary human hepatocytes and human chimeric mice. Notably, GT D virus exhibited higher infectivity than GTs A, B, C and E in vitro, although it was comparable to GT A and B in the human liver chimeric mice in vivo. HBV capsid inhibitors were more readily capable of suppressing HBV GTs A, B, D and E than C.en_US
dc.description.urihttps://doi.org/10.1016/j.jhepr.2022.100535en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJHEP Reportsen_US
dc.rights© 2022 The Authors.en_US
dc.subjectAAV, adeno-associated virusen_US
dc.subjectALT, alanine aminotransferaseen_US
dc.subjectBCP, basic core promoteren_US
dc.subjectCHB, chronic hepatitis Ben_US
dc.subjectCpAM, core protein allosteric modulatorsen_US
dc.subjectDR, direct repeaten_US
dc.subjectETV, entecaviren_US
dc.subjectEn, enhanceren_US
dc.subjectGT(s), genotype(s)en_US
dc.subjectHBV, hepatitis B virusen_US
dc.subjectHBVcc, cell culture-derived HBVen_US
dc.subjectHCC, hepatocellular carcinomaen_US
dc.subjectHDI, hydrodynamic injectionen_US
dc.subjectIFN, interferonen_US
dc.subjectIHC, immunohistochemistryen_US
dc.subjectIL, interleukinen_US
dc.subjectMOI, multiplicity of infectionen_US
dc.subjectNA, nucleos(t)ide analogueen_US
dc.subjectNRG, NODRag1−/−IL2RγNULLen_US
dc.subjectPHH, primiary human hepatocyteen_US
dc.subjectSVR, sustained virologic responseen_US
dc.subjectcccDNA, covalently closed circular DNAen_US
dc.subjectdpi, days post infectionen_US
dc.subjectdrug developmenten_US
dc.subjectgenotypesen_US
dc.subjecthepatitis Ben_US
dc.subjecthepatitis B virusen_US
dc.subjecthost responsesen_US
dc.subjectpgRNA, pre-genomic RNAen_US
dc.subjectreverse geneticsen_US
dc.subjectviral hepatitisen_US
dc.titleMolecular clones of genetically distinct hepatitis B virus genotypes reveal distinct host and drug treatment responses.en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jhepr.2022.100535
dc.identifier.pmid36035359
dc.source.journaltitleJHEP reports : innovation in hepatology
dc.source.volume4
dc.source.issue9
dc.source.beginpage100535
dc.source.endpage
dc.source.countryNetherlands


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record