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    Characterization of CD41 cells in the lymph node.

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    Author
    Dai, Li
    Uehara, Mayuko
    Li, Xiaofei
    LaBarre, Brenna A
    Banouni, Naima
    Ichimura, Takaharu
    Lee-Sundlov, Melissa M
    Kasinath, Vivek
    Sullivan, Jade A
    Ni, Heyu
    Barone, Francesca
    Giannini, Silvia
    Bahmani, Baharak
    Sage, Peter T
    Patsopoulos, Nikolaos A
    Tsokos, George C
    Bromberg, Jonathan S
    Hoffmeister, Karin
    Jiang, Liwei
    Abdi, Reza
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    Date
    2022-08-11
    Journal
    Frontiers in Immunology
    Publisher
    Frontiers
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2022.801945
    Abstract
    Lymph nodes (LNs) are the critical sites of immunity, and the stromal cells of LNs are crucial to their function. Our understanding of the stromal compartment of the LN has deepened recently with the characterization of nontraditional stromal cells. CD41 (integrin αIIb) is known to be expressed by platelets and hematolymphoid cells. We identified two distinct populations of CD41+Lyve1+ and CD41+Lyve1- cells in the LNs. CD41+Lyve1- cells appear in the LN mostly at the later stages of the lives of mice. We identified CD41+ cells in human LNs as well. We demonstrated that murine CD41+ cells express mesodermal markers, such as Sca-1, CD105 and CD29, but lack platelet markers. We did not observe the presence of platelets around the HEVs or within proximity to fibroblastic reticular cells of the LN. Examination of thoracic duct lymph fluid showed the presence of CD41+Lyve1- cells, suggesting that these cells recirculate throughout the body. FTY720 reduced their trafficking to lymph fluid, suggesting that their egress is controlled by the S1P1 pathway. CD41+Lyve1- cells of the LNs were sensitive to radiation, suggestive of their replicative nature. Single cell RNA sequencing data showed that the CD41+ cell population in naïve mouse LNs expressed largely stromal cell markers. Further studies are required to examine more deeply the role of CD41+ cells in the function of LNs.
    Rights/Terms
    Copyright © 2022 Dai, Uehara, Li, LaBarre, Banouni, Ichimura, Lee-Sundlov, Kasinath, Sullivan, Ni, Barone, Giannini, Bahmani, Sage, Patsopoulos, Tsokos, Bromberg, Hoffmeister, Jiang and Abdi.
    Keyword
    CD41 + progenitor cells
    lymph nodes
    lymphatic
    lymphatic remodeling
    stromal cells
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19647
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2022.801945
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