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dc.contributor.authorScozzi, Davide
dc.contributor.authorLiao, Fuyi
dc.contributor.authorKrupnick, Alexander S.
dc.contributor.authorKreisel, Daniel
dc.contributor.authorGelman, Andrew E.
dc.date.accessioned2022-08-30T14:29:57Z
dc.date.available2022-08-30T14:29:57Z
dc.date.issued2022-07-29
dc.identifier.urihttp://hdl.handle.net/10713/19646
dc.description.abstractAcute lung injury (ALI) is a heterogeneous inflammatory condition associated with high morbidity and mortality. Neutrophils play a key role in the development of different forms of ALI, and the release of neutrophil extracellular traps (NETs) is emerging as a common pathogenic mechanism. NETs are essential in controlling pathogens, and their defective release or increased degradation leads to a higher risk of infection. However, NETs also contain several pro-inflammatory and cytotoxic molecules than can exacerbate thromboinflammation and lung tissue injury. To reduce NET-mediated lung damage and inflammation, DNase is frequently used in preclinical models of ALI due to its capability of digesting NET DNA scaffold. Moreover, recent advances in neutrophil biology led to the development of selective NET inhibitors, which also appear to reduce ALI in experimental models. Here we provide an overview of the role of NETs in different forms of ALI discussing existing gaps in our knowledge and novel therapeutic approaches to modulate their impact on lung injury.en_US
dc.description.sponsorshipNational Institutes of Healthen_US
dc.description.urihttps://doi.org/10.3389/fimmu.2022.953195en_US
dc.language.isoen_USen_US
dc.publisherFrontiersen_US
dc.relation.ispartofFrontiers in Immunologyen_US
dc.subjectALI (acute lung injury)en_US
dc.subjectARDS (acute respiratory distress syndrome)en_US
dc.subjectCOVID-19en_US
dc.subjectDAMPs (damage-associated molecular patterns)en_US
dc.subjectinfections and sepsisen_US
dc.subjectNETs (neutrophil extracellular traps)en_US
dc.subjectsterile inflammatory responseen_US
dc.subjectThromboinflammationen_US
dc.titleThe role of neutrophil extracellular traps in acute lung injuryen_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fimmu.2022.953195
dc.source.journaltitleFrontiers in Immunology
dc.source.volume13


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