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dc.contributor.authorHopp, Jennifer
dc.contributor.authorPahlavan, Autusa
dc.contributor.authorRichert, Mary
dc.contributor.authorGrimes, Kathryn
dc.contributor.authorTurlington, Kate
dc.contributor.authorCassady, Maureen
dc.contributor.authorKvarta, Mark D
dc.contributor.authorThompson, Scott M
dc.date.accessioned2022-08-10T12:20:39Z
dc.date.available2022-08-10T12:20:39Z
dc.date.issued2022-07-22
dc.identifier.urihttp://hdl.handle.net/10713/19541
dc.description.abstractObjective: We tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in the peri-ictal period, much like the antidepressant effects of electroconvulsive therapy. Methods: We examined depression and anxiety symptoms in patients admitted to an inpatient unit for continuous video electroencephalography as part of routine clinical care. Patients completed three questionnaires that included the Beck Depression Inventory-II (BDI), Montgomery Asberg Depression Rating Scale (MADRS), and Beck Anxiety Inventory (BAI) after admission, in the 24 h following a seizure, then again 2 weeks after the last seizure. Results: In patients with epilepsy, depression and anxiety scores improved in the 24 hrs following a seizure (change in BDI = 24%; change in MADRS = 19%; change in BAI = 21%) but returned toward baseline after 2 weeks. In patients with non-epileptic seizures, depression and anxiety scores also improved in the 24 hrs following a psychogenic non-epileptic seizure (change in BDI = 17%, change in MADRS = 27%, change in BAI = 36%). There was a greater improvement in depression and anxiety scores in patients with focal-onset epilepsy (BDI = 30%, MADRS = 22%, BAI = 30%) compared to generalized seizure onset (BDI = 6%, MADRS = 12%, BAI = 8%). Conclusion: We conclude that single seizures can result in transient improvements in mood. Because seizures need not be generalized or epileptic to exert this effect, the underlying mechanisms are uncertain.en_US
dc.description.urihttps://doi.org/10.3389/fpsyt.2022.912697en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relationThe raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.en_US
dc.relation.ispartofFrontiers in Psychiatryen_US
dc.rightsCopyright © 2022 Hopp, Pahlavan, Richert, Grimes, Turlington, Cassady, Kvarta and Thompson.en_US
dc.subjectanxietyen_US
dc.subjectdepressionen_US
dc.subjectfocal epilepsiesen_US
dc.subjectgeneralized epilepsiesen_US
dc.subjectpsychogenic seizureen_US
dc.titlePeri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures.en_US
dc.typeArticleen_US
dc.identifier.doi10.3389/fpsyt.2022.912697
dc.identifier.pmid35935419
dc.source.journaltitleFrontiers in psychiatry
dc.source.volume13
dc.source.beginpage912697
dc.source.endpage
dc.source.countrySwitzerland


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