mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.
Author
Nanishi, EtsuroMcGrath, Marisa E
O'Meara, Timothy R
Barman, Soumik
Yu, Jingyou
Wan, Huahua
Dillen, Carly A
Menon, Manisha
Seo, Hyuk-Soo
Song, Kijun
Xu, Andrew Z
Sebastian, Luke
Brook, Byron
Bosco, Anna-Nicole
Borriello, Francesco
Ernst, Robert K
Barouch, Dan H
Dhe-Paganon, Sirano
Levy, Ofer
Frieman, Matthew B
Dowling, David J
Date
2022-08-06Journal
Communications BiologyPublisher
Springer NatureType
Article
Metadata
Show full item recordAbstract
The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, we evaluate multiple longitudinal immunization regimens of mRNA BNT162b2 to assess the effects of a booster dose provided >8 months after the primary immunization series across the murine lifespan, including in aged 21-month-old mice. Boosting dramatically enhances humoral and cell-mediated responses with evidence of Omicron cross-recognition. Furthermore, while younger mice are protected without a booster dose, boosting provides sterilizing immunity against Omicron-induced lung infection in aged 21-month-old mice. Correlational analyses reveal that neutralizing activity against Omicron is strongly associated with protection. Overall, our findings indicate age-dependent vaccine efficacy and demonstrate the potential benefit of mRNA booster immunization to protect vulnerable older populations against SARS-CoV-2 variants.Data Availibility
The authors declare that all data supporting the findings of this study are available within the supplementary information files (Supplementary Data 1 https://www.nature.com/articles/s42003-022-03765-3#MOESM4).Data / Code Location
https://www.nature.com/articles/s42003-022-03765-3#MOESM4Rights/Terms
© 2022. The Author(s).Identifier to cite or link to this item
http://hdl.handle.net/10713/19537ae974a485f413a2113503eed53cd6c53
10.1038/s42003-022-03765-3
Scopus Count
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