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    mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.

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    Author
    Nanishi, Etsuro
    McGrath, Marisa E
    O'Meara, Timothy R
    Barman, Soumik
    Yu, Jingyou
    Wan, Huahua
    Dillen, Carly A
    Menon, Manisha
    Seo, Hyuk-Soo
    Song, Kijun
    Xu, Andrew Z
    Sebastian, Luke
    Brook, Byron
    Bosco, Anna-Nicole
    Borriello, Francesco
    Ernst, Robert K
    Barouch, Dan H
    Dhe-Paganon, Sirano
    Levy, Ofer
    Frieman, Matthew B
    Dowling, David J
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    Date
    2022-08-06
    Journal
    Communications Biology
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s42003-022-03765-3
    Abstract
    The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, we evaluate multiple longitudinal immunization regimens of mRNA BNT162b2 to assess the effects of a booster dose provided >8 months after the primary immunization series across the murine lifespan, including in aged 21-month-old mice. Boosting dramatically enhances humoral and cell-mediated responses with evidence of Omicron cross-recognition. Furthermore, while younger mice are protected without a booster dose, boosting provides sterilizing immunity against Omicron-induced lung infection in aged 21-month-old mice. Correlational analyses reveal that neutralizing activity against Omicron is strongly associated with protection. Overall, our findings indicate age-dependent vaccine efficacy and demonstrate the potential benefit of mRNA booster immunization to protect vulnerable older populations against SARS-CoV-2 variants.
    Data Availibility
    The authors declare that all data supporting the findings of this study are available within the supplementary information files (Supplementary Data 1 https://www.nature.com/articles/s42003-022-03765-3#MOESM4).
    Data / Code Location
    https://www.nature.com/articles/s42003-022-03765-3#MOESM4
    Rights/Terms
    © 2022. The Author(s).
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19537
    ae974a485f413a2113503eed53cd6c53
    10.1038/s42003-022-03765-3
    Scopus Count
    Collections
    UMB Coronavirus Publications
    UMB Open Access Articles

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