• Login
    View Item 
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    •   UMB Digital Archive
    • UMB Open Access Articles
    • UMB Open Access Articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UMB Digital ArchiveCommunitiesPublication DateAuthorsTitlesSubjectsThis CollectionPublication DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    Statistics

    Display statistics

    Varying Oxygen Partial Pressure Elicits Blood-Borne Microparticles Expressing Different Cell-Specific Proteins-Toward a Targeted Use of Oxygen?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Balestra, Costantino
    Arya, Awadhesh K
    Leveque, Clément
    Virgili, Fabio
    Germonpré, Peter
    Lambrechts, Kate
    Lafère, Pierre
    Thom, Stephen R
    Date
    2022-07-17
    Journal
    International Journal of Molecular Sciences
    Publisher
    MDPI AG
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3390/ijms23147888
    Abstract
    Oxygen is a powerful trigger for cellular reactions, but there are few comparative investigations assessing the effects over a large range of partial pressures. We investigated a metabolic response to single exposures to either normobaric (10%, 15%, 30%, 100%) or hyperbaric (1.4 ATA, 2.5 ATA) oxygen. Forty-eight healthy subjects (32 males/16 females; age: 43.7 ± 13.4 years, height: 172.7 ± 10.07 cm; weight 68.4 ± 15.7 kg) were randomly assigned, and blood samples were taken before and 2 h after each exposure. Microparticles (MPs) expressing proteins specific to different cells were analyzed, including platelets (CD41), neutrophils (CD66b), endothelial cells (CD146), and microglia (TMEM). Phalloidin binding and thrombospondin-1 (TSP), which are related to neutrophil and platelet activation, respectively, were also analyzed. The responses were found to be different and sometimes opposite. Significant elevations were identified for MPs expressing CD41, CD66b, TMEM, and phalloidin binding in all conditions but for 1.4 ATA, which elicited significant decreases. Few changes were found for CD146 and TSP. Regarding OPB, further investigation is needed to fully understand the future applications of such findings.
    Keyword
    altitude
    cellular reactions
    decompression sickness
    diving
    hyperbaric oxygen
    hyperoxia
    hyperoxic-hypoxic paradox
    hypoxia
    normobaric oxygen paradox
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19496
    ae974a485f413a2113503eed53cd6c53
    10.3390/ijms23147888
    Scopus Count
    Collections
    UMB Open Access Articles

    entitlement

    Related articles

    • Hyperbaric Physics.
    • Authors: Jones MW, Brett K, Han N, Wyatt HA
    • Issue date: 2022 Jan
    • Association of microparticles and neutrophil activation with decompression sickness.
    • Authors: Thom SR, Bennett M, Banham ND, Chin W, Blake DF, Rosen A, Pollock NW, Madden D, Barak O, Marroni A, Balestra C, Germonpre P, Pieri M, Cialoni D, Le PN, Logue C, Lambert D, Hardy KR, Sward D, Yang M, Bhopale VB, Dujic Z
    • Issue date: 2015 Sep 1
    • Oxidative Stress Response's Kinetics after 60 Minutes at Different (30% or 100%) Normobaric Hyperoxia Exposures.
    • Authors: Leveque C, Mrakic-Sposta S, Lafère P, Vezzoli A, Germonpré P, Beer A, Mievis S, Virgili F, Lambrechts K, Theunissen S, Guerrero F, Balestra C
    • Issue date: 2022 Dec 30
    • Hyperbaric hyperoxia and normobaric reoxygenation increase excitability and activate oxygen-induced potentiation in CA1 hippocampal neurons.
    • Authors: Garcia AJ 3rd, Putnam RW, Dean JB
    • Issue date: 2010 Sep
    • Effect of in-water oxygen prebreathing at different depths on decompression-induced bubble formation and platelet activation.
    • Authors: Bosco G, Yang ZJ, Di Tano G, Camporesi EM, Faralli F, Savini F, Landolfi A, Doria C, Fanò G
    • Issue date: 2010 May
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Policies | Contact Us | UMB Health Sciences & Human Services Library
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.