Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol.
Author
Peacock, W FrankMaisel, Alan S
Mueller, Christian
Anker, Stefan D
Apple, Fred S
Christenson, Robert H
Collinson, Paul
Daniels, Lori B
Diercks, Deborah B
Somma, Salvatore Di
Filippatos, Gerasimos
Headden, Gary
Hiestand, Brian
Hollander, Judd E
Kaski, Juan C
Kosowsky, Joshua M
Nagurney, John T
Nowak, Richard M
Schreiber, Donald
Vilke, Gary M
Wayne, Marvin A
Than, Martin
Date
2022-06-30Journal
Clinical and Experimental Emergency MedicinePublisher
Korean Society of Emergency MedicineType
Article
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Show full item recordAbstract
Objective: To determine the utility of a highly sensitive troponin assay when utilized in the emergency department. Methods: The FAST-TRAC study prospectively enrolled >1,500 emergency department patients with suspected acute coronary syndrome within 6 hours of symptom onset and 2 hours of emergency department presentation. It has several unique features that are not found in the majority of studies evaluating troponin. These include a very early presenting population in whom prospective data collection of risk score parameters and the physician's clinical impression of the probability of acute coronary syndrome before any troponin data were available. Furthermore, two gold standard diagnostic definitions were determined by a pair of cardiologists reviewing two separate data sets; one that included all local troponin testing results and a second that excluded troponin testing so that diagnosis was based solely on clinical grounds. By this method, a statistically valid head-to-head comparison of contemporary and high sensitivity troponin testing is obtainable. Finally, because of a significant delay in sample processing, a unique ability to define the molecular stability of various troponin assays is possible. Trial registration: ClinicalTrials.gov Identifier NCT00880802.Keyword
Acute coronary syndromeCoronary artery disease
Emergency medicine
Myocardial infarction
Troponin
Identifier to cite or link to this item
http://hdl.handle.net/10713/19474ae974a485f413a2113503eed53cd6c53
10.15441/ceem.21.154
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