Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol.
AuthorPeacock, W Frank
Maisel, Alan S
Anker, Stefan D
Apple, Fred S
Christenson, Robert H
Daniels, Lori B
Diercks, Deborah B
Somma, Salvatore Di
Hollander, Judd E
Kaski, Juan C
Kosowsky, Joshua M
Nagurney, John T
Nowak, Richard M
Vilke, Gary M
Wayne, Marvin A
JournalClinical and Experimental Emergency Medicine
PublisherKorean Society of Emergency Medicine
MetadataShow full item record
AbstractObjective: To determine the utility of a highly sensitive troponin assay when utilized in the emergency department. Methods: The FAST-TRAC study prospectively enrolled >1,500 emergency department patients with suspected acute coronary syndrome within 6 hours of symptom onset and 2 hours of emergency department presentation. It has several unique features that are not found in the majority of studies evaluating troponin. These include a very early presenting population in whom prospective data collection of risk score parameters and the physician's clinical impression of the probability of acute coronary syndrome before any troponin data were available. Furthermore, two gold standard diagnostic definitions were determined by a pair of cardiologists reviewing two separate data sets; one that included all local troponin testing results and a second that excluded troponin testing so that diagnosis was based solely on clinical grounds. By this method, a statistically valid head-to-head comparison of contemporary and high sensitivity troponin testing is obtainable. Finally, because of a significant delay in sample processing, a unique ability to define the molecular stability of various troponin assays is possible. Trial registration: ClinicalTrials.gov Identifier NCT00880802.
KeywordAcute coronary syndrome
Coronary artery disease
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/19474
- A Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes: The Rapid Assessment of Possible Acute Coronary Syndrome in the Emergency Department With High-Sensitivity Troponin T Study (RAPID-TnT).
- Authors: Chew DP, Lambrakis K, Blyth A, Seshadri A, Edmonds MJR, Briffa T, Cullen LA, Quinn S, Karnon J, Chuang A, Nelson AJ, Wright D, Horsfall M, Morton E, French JK, Papendick C
- Issue date: 2019 Nov 5
- High-sensitivity troponin assays for early rule-out of acute myocardial infarction in people with acute chest pain: a systematic review and economic evaluation.
- Authors: Westwood M, Ramaekers B, Grimm S, Worthy G, Fayter D, Armstrong N, Buksnys T, Ross J, Joore M, Kleijnen J
- Issue date: 2021 May
- Diagnostic accuracy of contemporary and high-sensitivity cardiac troponin assays used in serial testing, versus single-sample testing as a comparator, to triage patients suspected of acute non-ST-segment elevation myocardial infarction: a systematic review protocol.
- Authors: Zhelev Z, Ohtake H, Iwata M, Terasawa T, Rogers M, Peters JL, Hyde C
- Issue date: 2019 Mar 30
- Diagnostic and prognostic utility of early measurement with high-sensitivity troponin T assay in patients presenting with chest pain.
- Authors: Aldous SJ, Richards M, Cullen L, Troughton R, Than M
- Issue date: 2012 Mar 20
- Ultra-Sensitive Copeptin and Cardiac Troponin in Diagnosing Non-ST-Segment Elevation Acute Coronary Syndromes--The COPACS Study.
- Authors: Ricci F, Di Scala R, Massacesi C, Di Nicola M, Cremonese G, De Pace D, Rossi S, Griffo I, Cataldo I, Martinotti S, Rotondo D, Jaffe AS, Zimarino M, De Caterina R
- Issue date: 2016 Jan