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dc.contributor.authorKamtchum-Tatuene, Joseph
dc.contributor.authorSaba, Luca
dc.contributor.authorHeldner, Mirjam R
dc.contributor.authorPoorthuis, Michiel H F
dc.contributor.authorBorst, Gert J de
dc.contributor.authorRundek, Tatjana
dc.contributor.authorKakkos, Stavros K
dc.contributor.authorChaturvedi, Seemant
dc.contributor.authorTopakian, Raffi
dc.contributor.authorPolak, Joseph F
dc.contributor.authorJickling, Glen C
dc.date.accessioned2022-07-14T12:49:56Z
dc.date.available2022-07-14T12:49:56Z
dc.date.issued2022-06-17
dc.identifier.urihttp://hdl.handle.net/10713/19372
dc.description.abstractDuplex carotid ultrasound was performed at baseline and 5 years. Baseline plaque severity was scored 0 to 5 based on North American Symptomatic Carotid Endarterectomy Trial grade of stenosis. Plaque vulnerability at baseline was the presence of markedly irregular, ulcerated, or echolucent plaques. Plaque progression at 5 years was a ≥1 point increase in stenosis severity. The relationship of baseline plasma IL-6 levels with plaque characteristics was modeled using multivariable linear (severity) or logistic (vulnerability and progression) regression. Risk factors of atherosclerosis were included as independent variables. Stepwise backward elimination was used with P>0.05 for variable removal. To assess model stability, we computed the E-value or minimum strength of association (odds ratio scale) that unmeasured confounders must have with log IL-6 and the outcome to suppress the association. We performed internal validation with 100 bootstrap samples.en_US
dc.description.urihttps://doi.org/10.1161/CIRCRESAHA.122.320877en_US
dc.language.isoenen_US
dc.publisherLippincott Williams and Wilkinsen_US
dc.relation.ispartofCirculation Researchen_US
dc.subjectatherosclerosisen_US
dc.subjectcarotid stenosisen_US
dc.subjectinflammationen_US
dc.subjectinterleukin-6en_US
dc.subjectstrokeen_US
dc.titleInterleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression.en_US
dc.typeArticleen_US
dc.identifier.doi10.1161/CIRCRESAHA.122.320877
dc.identifier.pmid35713008
dc.source.journaltitleCirculation research
dc.source.beginpage101161CIRCRESAHA122320877
dc.source.endpage
dc.source.countryUnited States


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