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    The Association Between Cardiometabolic Risk Factors and Frailty in Older Adults: A Systematic Review.

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    Author
    Shakya, Shamatree
    Bajracharya, Rashmita
    Ledbetter, Leila
    Cary, Michael P
    Date
    2022-05-25
    Journal
    Innovation in Aging
    Publisher
    Oxford University Press
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1093/geroni/igac032
    https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35795135/
    Abstract
    Background and objectives: Enhanced management and prevention of frailty depend on our understanding of the association between potentially modifiable risk factors and frailty. However, the associations between potentially modifiable cardiometabolic risk factors and frailty are not clear. The purpose of this review was to appraise and synthesize the current evidence examining the associations between the cardiometabolic risk factors and frailty. Research design and methods: Multiple databases, including MEDLINE (via PubMed), Embase (via Elsevier), and Web of Science (via Clarivate), were searched extensively. Studies that examined cardiometabolic risk factors and frailty as main predictors and outcome of interest, respectively, among older adults (≥60 years) were included. The Joanna Briggs Institute critical appraisal tools were used to evaluate the quality of studies. PRISMA (2020) guided this review, and findings were synthesized without meta-analysis. This systematic review was registered in PROSPERO (CRD42021252565). Results: Twelve studies met the eligibility criteria and were included in the review. Abdominal obesity, hyperglycemia, and multiple co-occurring cardiometabolic risk factors were associated with the increased likelihood of frailty in older adults. There was inconsistency across the studies regarding the associations between dyslipidemia, elevated blood pressure, and frailty. Discussion and implications: Understanding the association between cardiometabolic risk factors and frailty can have translational benefits in developing tailored interventions for the prevention and management of frailty. More studies are needed to validate predictive and clinically significant associations between single and specific combinations of co-occurring cardiometabolic risk factors and frailty.
    Rights/Terms
    © The Author(s) 2022. Published by Oxford University Press on behalf of The Gerontological Society of America.
    Keyword
    Cardiometabolic risk factors
    Frailty
    Inflammation
    Older adults
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19351
    ae974a485f413a2113503eed53cd6c53
    10.1093/geroni/igac032
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