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    Xenotransplantation: A New Era.

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    Author
    Carrier, Amber N
    Verma, Anjali
    Mohiuddin, Muhammad
    Pascual, Manuel
    Muller, Yannick D
    Longchamp, Alban
    Bhati, Chandra
    Buhler, Leo H
    Maluf, Daniel G
    Meier, Raphael P H
    Date
    2022-06-09
    Journal
    Frontiers in Immunology
    Publisher
    Frontiers Media S.A.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.3389/fimmu.2022.900594
    Abstract
    Organ allotransplantation has now reached an impassable ceiling inherent to the limited supply of human donor organs. In the United States, there are currently over 100,000 individuals on the national transplant waiting list awaiting a kidney, heart, and/or liver transplant. This is in contrast with only a fraction of them receiving a living or deceased donor allograft. Given the morbidity, mortality, costs, or absence of supportive treatments, xenotransplant has the potential to address the critical shortage in organ grafts. Last decade research efforts focused on creation of donor organs from pigs with various genes edited out using CRISPR technologies and utilizing non-human primates for trial. Three groups in the United States have recently moved forward with trials in human subjects and obtained initial successful results with pig-to-human heart and kidney xenotransplantation. This review serves as a brief discussion of the recent progress in xenotransplantation research, particularly as it concerns utilization of porcine heart, renal, and liver xenografts in clinical practice.
    Rights/Terms
    Copyright © 2022 Carrier, Verma, Mohiuddin, Pascual, Muller, Longchamp, Bhati, Buhler, Maluf and Meier.
    Keyword
    clinical trial
    heart
    kidney
    pig
    rejection
    xenograft
    xenotransplantation
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19298
    ae974a485f413a2113503eed53cd6c53
    10.3389/fimmu.2022.900594
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