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    A Direct Comparison of Physical Versus Dihydrocapsaicin-Induced Hypothermia in a Rat Model of Traumatic Spinal Cord Injury.

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    Author
    Sarkar, Amrita
    Kim, Kevin T
    Tsymbalyuk, Orest
    Keledjian, Kaspar
    Wilhelmy, Bradley E
    Sherani, Nageen A
    Jia, Xiaofeng
    Gerzanich, Volodymyr
    Simard, J Marc
    Date
    2021-10-07
    Journal
    Therapeutic Hypothermia and Temperature Management
    Publisher
    Mary Ann Liebert Inc.
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1089/ther.2021.0013
    https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35675523/
    Abstract
    Spinal cord injury (SCI) is a devastating neurological condition with no effective treatment. Hypothermia induced by physical means (cold fluid) is established as an effective therapy in animal models of SCI, but its clinical translation to humans is hampered by several constraints. Hypothermia induced pharmacologically may be noninferior or superior to physically induced hypothermia for rapid, convenient systemic temperature reduction, but it has not been investigated previously in animal models of SCI. We used a rat model of SCI to compare outcomes in three groups: (1) normothermic controls; (2) hypothermia induced by conventional physical means; (3) hypothermia induced by intravenous (IV) dihydrocapsaicin (DHC). Male rats underwent unilateral lower cervical SCI and were treated after a 4-hour delay with physical cooling or IV DHC (∼0.60 mg/kg total) cooling (both 33.0 ± 1.0°C) lasting 4 hours; controls were kept normothermic. Telemetry was used to monitor temperature and heart rate during and after treatments. In two separate experiments, one ending at 48 hours, the other at 6 weeks, "blinded" investigators evaluated rats in the three groups for neurological function followed by histopathological evaluation of spinal cord tissues. DHC reliably induced systemic cooling to 32-33°C. At both the time points examined, the two modes of hypothermia yielded similar improvements in neurological function and lesion size compared with normothermic controls. Our results indicate that DHC-induced hypothermia may be comparable with physical hypothermia in efficacy, but more clinically feasible to administer than physical hypothermia.
    Keyword
    SCI
    dihydrocapsaicin
    hypothermia
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19293
    ae974a485f413a2113503eed53cd6c53
    10.1089/ther.2021.0013
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