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    Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.

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    Author
    Winkler, Thomas W
    Rasheed, Humaira
    Teumer, Alexander
    Gorski, Mathias
    Rowan, Bryce X
    Stanzick, Kira J
    Thomas, Laurent F
    Tin, Adrienne
    Hoppmann, Anselm
    Chu, Audrey Y
    Tayo, Bamidele
    Thio, Chris H L
    Cusi, Daniele
    Chai, Jin-Fang
    Sieber, Karsten B
    Horn, Katrin
    Li, Man
    Scholz, Markus
    Cocca, Massimiliano
    Wuttke, Matthias
    van der Most, Peter J
    Yang, Qiong
    Ghasemi, Sahar
    Nutile, Teresa
    Li, Yong
    Pontali, Giulia
    Günther, Felix
    Dehghan, Abbas
    Correa, Adolfo
    Parsa, Afshin
    Feresin, Agnese
    de Vries, Aiko P J
    Zonderman, Alan B
    Smith, Albert V
    Oldehinkel, Albertine J
    De Grandi, Alessandro
    Rosenkranz, Alexander R
    Franke, Andre
    Teren, Andrej
    Metspalu, Andres
    Hicks, Andrew A
    Morris, Andrew P
    Tönjes, Anke
    Morgan, Anna
    Podgornaia, Anna I
    Peters, Annette
    Körner, Antje
    Mahajan, Anubha
    Campbell, Archie
    Freedman, Barry I
    Spedicati, Beatrice
    Ponte, Belen
    Schöttker, Ben
    Brumpton, Ben
    Banas, Bernhard
    Krämer, Bernhard K
    Jung, Bettina
    Åsvold, Bjørn Olav
    Smith, Blair H
    Ning, Boting
    Penninx, Brenda W J H
    Vanderwerff, Brett R
    Psaty, Bruce M
    Kammerer, Candace M
    Langefeld, Carl D
    Hayward, Caroline
    Spracklen, Cassandra N
    Robinson-Cohen, Cassianne
    Hartman, Catharina A
    Lindgren, Cecilia M
    Wang, Chaolong
    Sabanayagam, Charumathi
    Heng, Chew-Kiat
    Lanzani, Chiara
    Khor, Chiea-Chuen
    Cheng, Ching-Yu
    Fuchsberger, Christian
    Gieger, Christian
    Shaffer, Christian M
    Schulz, Christina-Alexandra
    Willer, Cristen J
    Chasman, Daniel I
    Gudbjartsson, Daniel F
    Ruggiero, Daniela
    Toniolo, Daniela
    Czamara, Darina
    Porteous, David J
    Waterworth, Dawn M
    Mascalzoni, Deborah
    Mook-Kanamori, Dennis O
    Reilly, Dermot F
    Daw, E Warwick
    Hofer, Edith
    Boerwinkle, Eric
    Salvi, Erika
    Bottinger, Erwin P
    Tai, E-Shyong
    Catamo, Eulalia
    Rizzi, Federica
    Guo, Feng
    Rivadeneira, Fernando
    Guilianini, Franco
    Sveinbjornsson, Gardar
    Ehret, Georg
    Waeber, Gerard
    Biino, Ginevra
    Girotto, Giorgia
    Pistis, Giorgio
    Nadkarni, Girish N
    Delgado, Graciela E
    Montgomery, Grant W
    Snieder, Harold
    Campbell, Harry
    White, Harvey D
    Gao, He
    Stringham, Heather M
    Schmidt, Helena
    Li, Hengtong
    Brenner, Hermann
    Holm, Hilma
    Kirsten, Holgen
    Kramer, Holly
    Rudan, Igor
    Nolte, Ilja M
    Tzoulaki, Ioanna
    Olafsson, Isleifur
    Martins, Jade
    Cook, James P
    Wilson, James F
    Halbritter, Jan
    Felix, Janine F
    Divers, Jasmin
    Kooner, Jaspal S
    Lee, Jeannette Jen-Mai
    O'Connell, Jeffrey
    Rotter, Jerome I
    Liu, Jianjun
    Xu, Jie
    Thiery, Joachim
    Ärnlöv, Johan
    Kuusisto, Johanna
    Jakobsdottir, Johanna
    Tremblay, Johanne
    Chambers, John C
    Whitfield, John B
    Gaziano, John M
    Marten, Jonathan
    Coresh, Josef
    Jonas, Jost B
    Mychaleckyj, Josyf C
    Christensen, Kaare
    Eckardt, Kai-Uwe
    Mohlke, Karen L
    Endlich, Karlhans
    Dittrich, Katalin
    Ryan, Kathleen A
    Rice, Kenneth M
    Taylor, Kent D
    Ho, Kevin
    Nikus, Kjell
    Matsuda, Koichi
    Strauch, Konstantin
    Miliku, Kozeta
    Hveem, Kristian
    Lind, Lars
    Wallentin, Lars
    Yerges-Armstrong, Laura M
    Raffield, Laura M
    Phillips, Lawrence S
    Launer, Lenore J
    Lyytikäinen, Leo-Pekka
    Lange, Leslie A
    Citterio, Lorena
    Klaric, Lucija
    Ikram, M Arfan
    Ising, Marcus
    Kleber, Marcus E
    Francescatto, Margherita
    Concas, Maria Pina
    Ciullo, Marina
    Piratsu, Mario
    Orho-Melander, Marju
    Laakso, Markku
    Loeffler, Markus
    Perola, Markus
    de Borst, Martin H
    Gögele, Martin
    Bianca, Martina La
    Lukas, Mary Ann
    Feitosa, Mary F
    Biggs, Mary L
    Wojczynski, Mary K
    Kavousi, Maryam
    Kanai, Masahiro
    Akiyama, Masato
    Yasuda, Masayuki
    Nauck, Matthias
    Waldenberger, Melanie
    Chee, Miao-Li
    Chee, Miao-Ling
    Boehnke, Michael
    Preuss, Michael H
    Stumvoll, Michael
    Province, Michael A
    Evans, Michele K
    O'Donoghue, Michelle L
    Kubo, Michiaki
    Kähönen, Mika
    Kastarinen, Mika
    Nalls, Mike A
    Kuokkanen, Mikko
    Ghanbari, Mohsen
    Bochud, Murielle
    Josyula, Navya Shilpa
    Martin, Nicholas G
    Tan, Nicholas Y Q
    Palmer, Nicholette D
    Pirastu, Nicola
    Schupf, Nicole
    Verweij, Niek
    Hutri-Kähönen, Nina
    Mononen, Nina
    Bansal, Nisha
    Devuyst, Olivier
    Melander, Olle
    Raitakari, Olli T
    Polasek, Ozren
    Manunta, Paolo
    Gasparini, Paolo
    Mishra, Pashupati P
    Sulem, Patrick
    Magnusson, Patrik K E
    Elliott, Paul
    Ridker, Paul M
    Hamet, Pavel
    Svensson, Per O
    Joshi, Peter K
    Kovacs, Peter
    Pramstaller, Peter P
    Rossing, Peter
    Vollenweider, Peter
    van der Harst, Pim
    Dorajoo, Rajkumar
    Sim, Ralene Z H
    Burkhardt, Ralph
    Tao, Ran
    Noordam, Raymond
    Mägi, Reedik
    Schmidt, Reinhold
    de Mutsert, Renée
    Rueedi, Rico
    van Dam, Rob M
    Carroll, Robert J
    Gansevoort, Ron T
    Loos, Ruth J F
    Felicita, Sala Cinzia
    Sedaghat, Sanaz
    Padmanabhan, Sandosh
    Freitag-Wolf, Sandra
    Pendergrass, Sarah A
    Graham, Sarah E
    Gordon, Scott D
    Hwang, Shih-Jen
    Kerr, Shona M
    Vaccargiu, Simona
    Patil, Snehal B
    Hallan, Stein
    Bakker, Stephan J L
    Lim, Su-Chi
    Lucae, Susanne
    Vogelezang, Suzanne
    Bergmann, Sven
    Corre, Tanguy
    Ahluwalia, Tarunveer S
    Lehtimäki, Terho
    Boutin, Thibaud S
    Meitinger, Thomas
    Wong, Tien-Yin
    Bergler, Tobias
    Rabelink, Ton J
    Esko, Tõnu
    Haller, Toomas
    Thorsteinsdottir, Unnur
    Völker, Uwe
    Foo, Valencia Hui Xian
    Salomaa, Veikko
    Vitart, Veronique
    Giedraitis, Vilmantas
    Gudnason, Vilmundur
    Jaddoe, Vincent W V
    Huang, Wei
    Zhang, Weihua
    Wei, Wen Bin
    Kiess, Wieland
    März, Winfried
    Koenig, Wolfgang
    Lieb, Wolfgang
    Gao, Xin
    Sim, Xueling
    Wang, Ya Xing
    Friedlander, Yechiel
    Tham, Yih-Chung
    Kamatani, Yoichiro
    Okada, Yukinori
    Milaneschi, Yuri
    Yu, Zhi
    Stark, Klaus J
    Stefansson, Kari
    Böger, Carsten A
    Hung, Adriana M
    Kronenberg, Florian
    Köttgen, Anna
    Pattaro, Cristian
    Heid, Iris M
    Show allShow less

    Date
    2022-06-13
    Journal
    Communications Biology
    Publisher
    Springer Nature
    Type
    Article
    
    Metadata
    Show full item record
    See at
    https://doi.org/10.1038/s42003-022-03448-z
    Abstract
    Reduced glomerular filtration rate (GFR) can progress to kidney failure. Risk factors include genetics and diabetes mellitus (DM), but little is known about their interaction. We conducted genome-wide association meta-analyses for estimated GFR based on serum creatinine (eGFR), separately for individuals with or without DM (nDM = 178,691, nnoDM = 1,296,113). Our genome-wide searches identified (i) seven eGFR loci with significant DM/noDM-difference, (ii) four additional novel loci with suggestive difference and (iii) 28 further novel loci (including CUBN) by allowing for potential difference. GWAS on eGFR among DM individuals identified 2 known and 27 potentially responsible loci for diabetic kidney disease. Gene prioritization highlighted 18 genes that may inform reno-protective drug development. We highlight the existence of DM-only and noDM-only effects, which can inform about the target group, if respective genes are advanced as drug targets. Largely shared effects suggest that most drug interventions to alter eGFR should be effective in DM and noDM.
    Rights/Terms
    © 2022. The Author(s).
    Identifier to cite or link to this item
    http://hdl.handle.net/10713/19180
    ae974a485f413a2113503eed53cd6c53
    10.1038/s42003-022-03448-z
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