Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.
Freidin, Maxim B
Oosterloo, Berthe C
Chasman, Daniel I
Concas, Maria Pina
Giersch, Anne B S
Heard-Costa, Nancy L
Hjelmborg, Jacob V B
Hoffman, Howard J
Kähler, Anna K
Launer, Lenore J
Magnusson, Patrik K E
van Meurs, Joyce
Morton, Cynthia C
Nalls, Mike A
Nardone, Giuseppe Giovanni
Satizabal Barrera, Claudia L
Schweinfurth, John M
Lauschke, Volker M
Sullivan, Patrick F
Cederroth, Christopher R
Williams, Frances M K
Nagtegaal, Andries Paul
JournalAmerican Journal of Human Genetics
MetadataShow full item record
AbstractHearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. A large proportion of associations comprised missense variants, half of which lie within known familial hearing loss loci. We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. Our findings indicate the importance of the stria vascularis in the mechanism of hearing impairment, providing future paths for developing targets for therapeutic intervention in hearing loss.
Data AvailibilityThe GWAS summary statistics are deposited and available in Zenodo (https://zenodo.org/record/5769707#.Ybm6v33MKhx) and codes are available on GitHub (https://github.com/translational-audiology-lab/GWAS_ARHL).
Data / Code Locationhttps://zenodo.org/record/5769707#.Ybm6v33MKhx; https://github.com/translational-audiology-lab/GWAS_ARHL
Rights/TermsCopyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
Identifier to cite or link to this itemhttp://hdl.handle.net/10713/19053
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