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dc.contributor.authorChen, Yandi
dc.contributor.authorYang, Bina
dc.contributor.authorCheng, Lei
dc.contributor.authorXu, Hockin H K
dc.contributor.authorLi, Hao
dc.contributor.authorHuang, Yuyao
dc.contributor.authorZhang, Qiong
dc.contributor.authorZhou, Xuedong
dc.contributor.authorLiang, Jingou
dc.contributor.authorZou, Jing
dc.date.accessioned2022-05-31T13:57:39Z
dc.date.available2022-05-31T13:57:39Z
dc.date.issued2022-05-14
dc.identifier.urihttp://hdl.handle.net/10713/19027
dc.description.abstractThe objective of this study was to develop novel modified giomers by incorporating the antibacterial quaternary ammonium monomers (QAMs), dimethylaminododecyl methacrylate (DMADDM) or dimethylaminohexadecyl methacrylate (DMAHDM) into a commercial giomer. The material performances including mechanical properties, surface characteristics, color data, cytotoxicity and fluoride release of the novel giomers were evaluated. Antibacterial activity against severe early childhood caries (S-ECC) saliva-derived biofilms was assessed by lactic acid production measurement, MTT assay, biofilm staining and 16S rRNA sequencing. A rat model was developed and the anti-caries effect was investigated by micro-CT scanning and modified Keyes' scoring. The results showed that the material properties of the QAMs groups were comparable to those of the control group. The novel giomers significantly inhibited lactic acid production and biofilm viability of S-ECC saliva-derived biofilms. Furthermore, caries-related genera such as Streptococcus and Lactobacillus reduced in QAMs groups, which showed their potential to change the microbial compositions. In the rat model, lesion depth, mineral loss and scoring of the QAMs groups were significantly reduced, without side effects on oral tissues. In conclusion, the novel giomers incorporated with antibacterial QAMs could inhibit the cariogenic biofilms and help prevent secondary caries, with great potential for future application in restorative treatment.en_US
dc.description.urihttps://doi.org/10.3390/pathogens11050578en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.relation.ispartofPathogens (Basel, Switzerland)en_US
dc.subjectantibacterial quaternary ammonium monomersen_US
dc.subjectbiofilmsen_US
dc.subjectearly childhood cariesen_US
dc.subjectgiomersen_US
dc.subjectsecondary cariesen_US
dc.titleNovel Giomers Incorporated with Antibacterial Quaternary Ammonium Monomers to Inhibit Secondary Caries.en_US
dc.typeArticleen_US
dc.identifier.doi10.3390/pathogens11050578
dc.identifier.pmid35631099
dc.source.journaltitlePathogens (Basel, Switzerland)
dc.source.volume11
dc.source.issue5
dc.source.countrySwitzerland


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